Regulatory Network in Protein Phosphorylation
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Substrate: CANX

Description: Calnexin precursor (Major histocompatibility complex class I antigen-binding protein p88) (p90) (IP90).

Ensembl ID: ENSG00000127022

UniprotKB/SwissProt: CALX_HUMAN (P27824)

Function: Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CANX

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CANXCALX_HUMANS554EEKQK S DAEED 39.29% Swiss-Prot 55.0 View   
2CANXCALX_HUMANS554EEKQK S DAEED 39.29% HPRD:00252(in vivo)View   
3CANXCALX_HUMANS554EEKQK S DAEED 39.29%CK2_group Phospho.ELM 7.0 ViewAnalyzing
4CANXCALX_HUMANT562EEDGG T VSQEE 23.63% Phospho.ELM 7.0View   
5CANXCALX_HUMANT562EEDGG T VSQEE 23.63% HPRD:00252(in vivo)View   
6CANXCALX_HUMANT562EEDGG T VSQEE 23.63% Swiss-Prot 55.0 View   
7CANXCALX_HUMANS564DGGTV S QEEED 31.54%CK2_group Phospho.ELM 7.0 ViewAnalyzing
8CANXCALX_HUMANS564DGGTV S QEEED 31.54% HPRD:00252(in vivo)View   
9CANXCALX_HUMANS564DGGTV S QEEED 31.54% Swiss-Prot 55.0 View   
10CANXCALX_HUMANS583EILNR S PRNRK 27.43% Swiss-Prot 55.0 View   
11CANXCALX_HUMANS583EILNR S PRNRK 27.43% HPRD:00252(in vivo)View   
12CANXCALX_HUMANS583EILNR S PRNRK 27.43%PKC_group Phospho.ELM 7.0 ViewAnalyzing