Regulatory Network in Protein Phosphorylation
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Substrate: CCNH

Description: Cyclin-H (MO15-associated protein) (p37) (p34).

Ensembl ID: ENSG00000134480

UniprotKB/SwissProt: CCNH_HUMAN (P51946)

Function: Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
PDB:1JKW
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CCNH

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CCNHCCNH_HUMANS5-MYHN S SQKRH 22.34%CDK8 Swiss-Prot 55.0   ViewAnalyzing
2CCNHCCNH_HUMANS5-MYHN S SQKRH 22.34%CDK8 HPRD:09059(in vitro;in vivo)  ViewAnalyzing
3CCNHCCNH_HUMANS304DDDYV S KKSKH 28.30%CDK8 Swiss-Prot 55.0   ViewAnalyzing
4CCNHCCNH_HUMANS304DDDYV S KKSKH 28.30%CDK8 HPRD:09059(in vitro;in vivo)  ViewAnalyzing
5CCNHCCNH_HUMANT315EEEEW T DDDLV 32.60% Swiss-Prot 55.0 View   
6CCNHCCNH_HUMANT315EEEEW T DDDLV 32.60%CK2_group Phospho.ELM 7.0 ViewAnalyzing