Regulatory Network in Protein Phosphorylation
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Substrate: CDH1

Description: Epithelial cadherin precursor (E-cadherin) (Uvomorulin) (Cadherin-1)(CAM 120/80) (CD324 antigen) [Contains: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3].

Synonyms: CDHE, UVO

Ensembl ID: ENSG00000039068

UniprotKB/SwissProt: CADH1_HUMAN (P12830)

Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell junction. Cell membrane; Single-pass type I membrane protein. Note=Colocalizes with DLG7 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequent
PDB:1O6S
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CDH1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CDH1CADH1_HUMANS838FDYEG S GSEAA 27.49% Swiss-Prot 55.0 (Similarity)View   
2CDH1CADH1_HUMANS838FDYEG S GSEAA 27.49%CK2a1 HPRD:01885(in vitro;in vivo)  ViewAnalyzing
3CDH1CADH1_HUMANS838FDYEG S GSEAA 27.49%CK2a1-rs HPRD:01885(in vitro;in vivo)  ViewAnalyzing
4CDH1CADH1_HUMANS840YEGSG S EAASL 26.26% Swiss-Prot 55.0 (Similarity)View   
5CDH1CADH1_HUMANS846EAASL S SLNSS 30.22% Swiss-Prot 55.0 (Similarity)View   
6CDH1CADH1_HUMANS847AASLS S LNSSE 36.54%CK2a1 HPRD:01885(in vitro)  ViewAnalyzing
7CDH1CADH1_HUMANS847AASLS S LNSSE 36.54%CK2a1-rs HPRD:01885(in vitro)  ViewAnalyzing
8CDH1CADH1_HUMANS847AASLS S LNSSE 36.54%GSK3B HPRD:01885(in vitro)  ViewAnalyzing
9CDH1CADH1_HUMANS851SSLNS S ESDKD 39.79%CK2a1-rs HPRD:01885(in vitro)  ViewAnalyzing
10CDH1CADH1_HUMANS851SSLNS S ESDKD 39.79%CK2a1 HPRD:01885(in vitro)  ViewAnalyzing
11CDH1CADH1_HUMANS851SSLNS S ESDKD 39.79%CK2_group Phospho.ELM 7.0 ViewAnalyzing
12CDH1CADH1_HUMANS853LNSSE S DKDQD 52.49%CK2a1 HPRD:01885(in vitro;in vivo)  ViewAnalyzing
13CDH1CADH1_HUMANS853LNSSE S DKDQD 52.49%CK2a1-rs HPRD:01885(in vitro;in vivo)  ViewAnalyzing