Regulatory Network in Protein Phosphorylation
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Substrate: DPYSL2

Description: Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin responsemediator protein 2) (CRMP-2) (N2A3).

Synonyms: CRMP2

Ensembl ID: ENSG00000092964

UniprotKB/SwissProt: DPYL2_HUMAN (Q16555)

Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity).
PDB:2GSE
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of DPYSL2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1DPYSL2DPYL2_HUMANY32DDQSF Y ADIYM 14.49% Swiss-Prot 55.0 (Similarity)View   
2DPYSL2DPYL2_HUMANY431NSSLE Y NIFEG 20.89% Swiss-Prot 55.0 (Similarity)View   
3DPYSL2DPYL2_HUMANT462GTLHV T EGSGR 24.71% Swiss-Prot 55.0 (Similarity)View   
4DPYSL2DPYL2_HUMANS465HVTEG S GRYIP 17.54% Swiss-Prot 55.0 (Similarity)View   
5DPYSL2DPYL2_HUMANY499VPRGL Y DGPVC 22.98% Swiss-Prot 55.0 (Similarity)View   
6DPYSL2DPYL2_HUMANT509CEVSV T PKTVT 16.15% HPRD:03914(in vitro)View   
7DPYSL2DPYL2_HUMANT509CEVSV T PKTVT 16.15%GSK3B(GSK3 beta) Phospho.ELM 7.0 ViewAnalyzing
8DPYSL2DPYL2_HUMANT509CEVSV T PKTVT 16.15% Swiss-Prot 55.0 View   
9DPYSL2DPYL2_HUMANT514TPKTV T PASSA 20.54% Swiss-Prot 55.0 View   
10DPYSL2DPYL2_HUMANT514TPKTV T PASSA 20.54%GSK3B(GSK3 beta) Phospho.ELM 7.0 ViewAnalyzing
11DPYSL2DPYL2_HUMANS518VTPAS S AKTSP 35.57%GSK3B(GSK3 beta) Phospho.ELM 7.0 ViewAnalyzing
12DPYSL2DPYL2_HUMANS518VTPAS S AKTSP 35.57% Swiss-Prot 55.0 View   
13DPYSL2DPYL2_HUMANS522SSAKT S PAKQQ 23.35% Phospho.ELM 7.0View   
14DPYSL2DPYL2_HUMANS522SSAKT S PAKQQ 23.35% Swiss-Prot 55.0 View   
15DPYSL2DPYL2_HUMANT555IPRRT T QRIVA 17.65%ROCK_group Phospho.ELM 7.0 ViewAnalyzing
16DPYSL2DPYL2_HUMANT555IPRRT T QRIVA 17.65%ROCK2 Phospho.ELM 7.0  ViewAnalyzing
17DPYSL2DPYL2_HUMANT555IPRRT T QRIVA 17.65%ROCK1 HPRD:03914(in vitro)  ViewAnalyzing