Regulatory Network in Protein Phosphorylation
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Substrate: EIF4EBP1

Description: Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1)(eIF4E-binding protein 1) (Phosphorylated heat- and acid-stableprotein regulated by insulin 1) (PHAS-I).

Ensembl ID: ENSG00000187840

UniprotKB/SwissProt: 4EBP1_HUMAN (Q13541)

Function: Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
PDB:1WKW
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of EIF4EBP1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1EIF4EBP14EBP1_HUMANS8GGSSC S QTPSR 38.75%ATM Phospho.ELM 7.0  ViewAnalyzing
2EIF4EBP14EBP1_HUMANT36PGDYS T TPGGT 30.68%MSK1 HPRD:03746(in vitro)  ViewAnalyzing
3EIF4EBP14EBP1_HUMANT37GDYST T PGGTL 17.62%AKT1 HPRD:03746(in vitro)  ViewAnalyzing
4EIF4EBP14EBP1_HUMANT37GDYST T PGGTL 17.62%FRAP(mTOR) Phospho.ELM 7.0 ViewAnalyzing
5EIF4EBP14EBP1_HUMANT37GDYST T PGGTL 17.62%Erk2 HPRD:03746(in vitro;in vivo)  ViewAnalyzing
6EIF4EBP14EBP1_HUMANT37GDYST T PGGTL 17.62%FRAP HPRD:03746(in vitro;in vivo)  ViewAnalyzing
7EIF4EBP14EBP1_HUMAN