Regulatory Network in Protein Phosphorylation
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Substrate: EIF5

Description: Eukaryotic translation initiation factor 5 (eIF-5).

Ensembl ID: ENSG00000100664

UniprotKB/SwissProt: IF5_HUMAN (P55010)

Function: Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
PDB:2G2K
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of EIF5

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1EIF5IF5_HUMANS149NPPEN S DSGTG 31.34% Swiss-Prot 55.0 View   
2EIF5IF5_HUMANS174ENGSV S SSETP 29.82%CK2a1-rs HPRD:03417(in vitro)  ViewAnalyzing
3EIF5IF5_HUMANS174ENGSV S SSETP 29.82%CK2a1 HPRD:03417(in vitro)  ViewAnalyzing
4EIF5IF5_HUMANS174ENGSV S SSETP 29.82%P67870(Casein kinase II, beta) HPRD:03417(in vitro;in vivo) ViewAnalyzing
5EIF5IF5_HUMANS389EAEEE S SGGEE 37.25%P67870(Casein kinase II, beta) HPRD:03417(in vitro;in vivo) ViewAnalyzing
6EIF5IF5_HUMANS389EAEEE S SGGEE 37.25%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
7EIF5IF5_HUMANS389EAEEE S SGGEE 37.25%CK2a1 HPRD:03417(in vitro;in vivo)  ViewAnalyzing
8EIF5IF5_HUMANS389EAEEE S SGGEE 37.25% Swiss-Prot 55.0 View   
9EIF5IF5_HUMANS389EAEEE S SGGEE 37.25%CK2a1-rs HPRD:03417(in vitro;in vivo)  ViewAnalyzing
10EIF5IF5_HUMANS390AEEES S GGEEE 54.84%P67870(Casein kinase II, beta) HPRD:03417(in vitro;in vivo) ViewAnalyzing
11EIF5IF5_HUMANS390AEEES S GGEEE 54.84%CK2a1-rs HPRD:03417(in vitro;in vivo)  ViewAnalyzing
12EIF5IF5_HUMANS390AEEES S GGEEE 54.84%CK2a1 HPRD:03417(in vitro;in vivo)  ViewAnalyzing
13EIF5IF5_HUMANS390AEEES S GGEEE 54.84% Swiss-Prot 55.0 View   
14EIF5IF5_HUMANS390AEEES S GGEEE 54.84%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
15EIF5IF5_HUMANY405NIEVV Y SKAAS 15.05% Swiss-Prot 55.0 View   
16EIF5IF5_HUMANS410YSKAA S VPKVE 43.76% Swiss-Prot 55.0 View