Regulatory Network in Protein Phosphorylation
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Substrate: FURIN

Description: Furin precursor (EC 3.4.21.75) (Paired basic amino acid residuecleaving enzyme) (PACE) (Dibasic-processing enzyme).

Synonyms: FUR, PACE, PCSK3

Ensembl ID: ENSG00000140564

UniprotKB/SwissProt: FURIN_HUMAN (P09958)

Function: Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of FURIN

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1FURINFURIN_HUMANS773QEECP S DSEED 66.48%CK2_group Swiss-Prot 55.0  ViewAnalyzing
2FURINFURIN_HUMANS775ECPSD S EEDEG 47.42%CK2_group Swiss-Prot 55.0  ViewAnalyzing