Regulatory Network in Protein Phosphorylation
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Substrate: HCLS1

Description: Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75).

Synonyms: HS1

Ensembl ID: ENSG00000180353

UniprotKB/SwissProt: HCLS1_HUMAN (P14317)

Function: Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Peripheral membrane protein (Probable). Cytoplasm (Probable). Mitochondrion (Probable).
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of HCLS1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1HCLS1HCLS1_HUMANT16SVSVE T QGDDW 35.38%CK2a1 HPRD:03199(in vitro)  ViewAnalyzing
2HCLS1HCLS1_HUMANT16SVSVE T QGDDW 35.38%CK2a1-rs HPRD:03199(in vitro)  ViewAnalyzing
3HCLS1HCLS1_HUMANT23GDDWD T DPDFV 45.22%CK2a1-rs HPRD:03199(in vitro)  ViewAnalyzing
4HCLS1HCLS1_HUMANT23GDDWD T DPDFV 45.22%CK2a1 HPRD:03199(in vitro)  ViewAnalyzing
5HCLS1HCLS1_HUMANY103AVGHE Y VAEVE 10.17% HPRD:03199(in vivo)View   
6HCLS1HCLS1_HUMANY103AVGHE Y VAEVE 10.17% Phospho.ELM 7.0View   
7HCLS1HCLS1_HUMANY103AVGHE Y VAEVE 10.17% Swiss-Prot 55.0 View   
8HCLS1HCLS1_HUMANY140AVGFD Y KGEVE 20.73% Swiss-Prot 55.0 (Similarity)View   
9HCLS1HCLS1_HUMANY198GFGGQ Y GIQKD 21.33% Swiss-Prot 55.0 View   
10HCLS1HCLS1_HUMANY198GFGGQ Y GIQKD 21.33% HPRD:03199(in vitro)View   
11HCLS1HCLS1_HUMANY198GFGGQ Y GIQKD 21.33% Phospho.ELM 7.0View   
12HCLS1HCLS1_HUMANY222APTTA Y KKTTP 15.78%FGR HPRD:03199(in vitro;in vivo)  ViewAnalyzing
13HCLS1HCLS1_HUMANY222APTTA Y KKTTP 15.78%Fgr Phospho.ELM 7.0  ViewAnalyzing
14HCLS1HCLS1_HUMANY222APTTA Y KKTTP 15.78%LYN HPRD:03199(in vitro)  ViewAnalyzing
15HCLS1HCLS1_HUMANY222APTTA Y KKTTP 15.78%Lyn Phospho.ELM 7.0  ViewAnalyzing
16HCLS1HCLS1_HUMANY222APTTA Y KKTTP 15.78% Swiss-Prot 55.0 View   
17HCLS1HCLS1_HUMANS275AVTKR S PEAPQ 28.75% Phospho.ELM 7.0View   
18HCLS1HCLS1_HUMANS275AVTKR S PEAPQ 28.75% HPRD:03199(in vivo)View   
19HCLS1HCLS1_HUMANS275AVTKR S PEAPQ 28.75% Swiss-Prot 55.0 View   
20HCLS1HCLS1_HUMANY360EEEPV Y EAEPE 21.82% Phospho.ELM 7.0View   
21HCLS1HCLS1_HUMANY378EPEND Y EDVEE 26.13%Lyn Phospho.ELM 7.0  ViewAnalyzing
22HCLS1HCLS1_HUMANY378EPEND Y EDVEE 26.13%SYK HPRD:03199(in vitro)  ViewAnalyzing
23HCLS1HCLS1_HUMANY378EPEND Y EDVEE 26.13%Syk Phospho.ELM 7.0  ViewAnalyzing
24HCLS1HCLS1_HUMANY378EPEND Y EDVEE 26.13%LYN HPRD:03199(in vitro)  ViewAnalyzing
25HCLS1HCLS1_HUMANY397EPEGD Y EEVLE 25.50%Lyn Phospho.ELM 7.0  ViewAnalyzing
26HCLS1HCLS1_HUMANY397EPEGD Y EEVLE 25.50%LYN HPRD:03199(in vitro)  ViewAnalyzing
27HCLS1HCLS1_HUMANY397EPEGD Y EEVLE 25.50%SYK HPRD:03199(in vitro)  ViewAnalyzing
28HCLS1HCLS1_HUMANY397EPEGD Y EEVLE 25.50%Syk Phospho.ELM 7.0  ViewAnalyzing
29HCLS1HCLS1_HUMANY397EPEGD Y EEVLE 25.50%Fgr Phospho.ELM 7.0  ViewAnalyzing