Regulatory Network in Protein Phosphorylation
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Substrate: HDAC2

Description: Histone deacetylase 2 (HD2).

Ensembl ID: ENSG00000196591

UniprotKB/SwissProt: HDAC2_HUMAN (Q92769)

Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of HDAC2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1HDAC2HDAC2_HUMANS394AVHED S GDEDG 45.20% Swiss-Prot 55.0 View   
2HDAC2HDAC2_HUMANS394AVHED S GDEDG 45.20%CK2a1-rs HPRD:05521(in vitro;in vivo)  ViewAnalyzing
3HDAC2HDAC2_HUMANS394AVHED S GDEDG 45.20%CK2_group Phospho.ELM 7.0 ViewAnalyzing
4HDAC2HDAC2_HUMANS394AVHED S GDEDG 45.20%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
5HDAC2HDAC2_HUMANS394AVHED S GDEDG 45.20%CK2a1 HPRD:05521(in vitro;in vivo)  ViewAnalyzing
6HDAC2HDAC2_HUMANS394AVHED S GDEDG 45.20%CK2a2 HPRD:05521(in vitro)  ViewAnalyzing
7HDAC2HDAC2_HUMANS407PDKRI S IRASD 15.28% Swiss-Prot 55.0 View   
8HDAC2HDAC2_HUMANS422CDEEF S DSEDE 43.43%CK2a2 HPRD:05521(in vitro)  ViewAnalyzing
9HDAC2HDAC2_HUMANS422CDEEF S DSEDE 43.43%CK2a1-rs HPRD:05521(in vitro)  ViewAnalyzing
10HDAC2HDAC2_HUMANS422CDEEF S DSEDE 43.43%CK2_group Phospho.ELM 7.0 ViewAnalyzing
11HDAC2HDAC2_HUMANS422CDEEF S DSEDE 43.43% Swiss-Prot 55.0 View   
12HDAC2HDAC2_HUMANS422CDEEF S DSEDE 43.43%CK2a1 HPRD:05521(in vitro)  ViewAnalyzing
13HDAC2HDAC2_HUMANS424EEFSD S EDEGE 45.83%CK2a1 HPRD:05521(in vitro)  ViewAnalyzing
14HDAC2HDAC2_HUMANS424EEFSD S EDEGE 45.83%CK2_group Phospho.ELM 7.0 ViewAnalyzing
15HDAC2HDAC2_HUMANS424EEFSD S EDEGE 45.83% Swiss-Prot 55.0 View   
16HDAC2HDAC2_HUMANS424EEFSD S EDEGE 45.83%CK2a2 HPRD:05521(in vitro)  ViewAnalyzing
17HDAC2HDAC2_HUMANS424EEFSD S EDEGE 45.83%CK2a1-rs HPRD:05521(in vitro)  ViewAnalyzing