Regulatory Network in Protein Phosphorylation
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Substrate: HDAC3

Description: Histone deacetylase 3 (HD3) (RPD3-2) (SMAP45).

Ensembl ID: ENSG00000171720

UniprotKB/SwissProt: HDAC3_HUMAN (O15379)

Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of HDAC3

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1HDAC3HDAC3_HUMANS424DNDKE S DVEI 53.34% Phospho.ELM 7.0View   
2HDAC3HDAC3_HUMANS424DNDKE S DVEI 53.34%CK2a1 HPRD:08950(in vitro)  ViewAnalyzing
3HDAC3HDAC3_HUMANS424DNDKE S DVEI 53.34%CK2a1-rs HPRD:08950(in vitro)  ViewAnalyzing