Regulatory Network in Protein Phosphorylation
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Substrate: HIF1A

Description: Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT-interacting protein) (Member of PAS protein 1) (Basic-helix-loop-helix-PAS protein MOP1).

Synonyms: MOP1

Ensembl ID: ENSG00000100644

UniprotKB/SwissProt: HIF1A_HUMAN (Q16665)

Function: Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions activates the transcription of over 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Cytoplasmic in normoxia, nuclear translocation in response to hypoxia.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of HIF1A

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1HIF1AHIF1A_HUMANT796GLPQL T SYDCE 21.72% Phospho.ELM 7.0View   
2HIF1AHIF1A_HUMANT796GLPQL T SYDCE 21.72%CK2a1 HPRD:04517(in vitro)  ViewAnalyzing
3HIF1AHIF1A_HUMANT796GLPQL T SYDCE 21.72%CK2a1-rs HPRD:04517(in vitro)  ViewAnalyzing