Regulatory Network in Protein Phosphorylation
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Substrate: HNRNPC

Description: Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1 / hnRNP C2).

Synonyms: HNRPC

Ensembl ID: ENSG00000092199

UniprotKB/SwissProt: HNRPC_HUMAN (P07910)

Function: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Note=Component of ribonucleosomes.
PDB:1TXP
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of HNRNPC

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1HNRNPCHNRPC_HUMANS138YDRMY S YPARV 18.46% Swiss-Prot 55.0 View   
2HNRNPCHNRPC_HUMANS162KRQRV S GNTSR 28.63% Phospho.ELM 7.0View   
3HNRNPCHNRPC_HUMANS162KRQRV S GNTSR 28.63% Swiss-Prot 55.0 View   
4