Regulatory Network in Protein Phosphorylation
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Substrate: IFI16

Description: Gamma-interferon-inducible protein Ifi-16 (Interferon-induciblemyeloid differentiation transcriptional activator) (IFI 16).

Synonyms: IFNGIP1

Ensembl ID: ENSG00000163565

UniprotKB/SwissProt: IF16_HUMAN (Q16666)

Function: May function as a transcriptional repressor. Could have a role in the regulation of hematopoeitic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53 and the retinoblastoma protein. May be involved in the senescence of prostate epithelial cells.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
PDB:2OQ0
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of IFI16

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1IFI16IF16_HUMANS106EVDAT S PAPST 22.30% Swiss-Prot 55.0 View   
2IFI16IF16_HUMANS132QKRKK S TKEKA 47.98%CK2a1-rs HPRD:00969(in vitro)  ViewAnalyzing
3IFI16IF16_HUMANS132QKRKK S TKEKA 47.98%CK2a1 HPRD:00969(in vitro)  ViewAnalyzing
4IFI16IF16_HUMANS132QKRKK S TKEKA 47.98%CK2_group Phospho.ELM 7.0 ViewAnalyzing
5IFI16IF16_HUMANS132QKRKK S TKEKA 47.98%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
6IFI16IF16_HUMANS153QTQPP S PAGAG 33.78% Swiss-Prot 55.0 View   
7IFI16IF16_HUMANS153QTQPP S PAGAG 33.78% Phospho.ELM 7.0View   
8IFI16IF16_HUMANS153QTQPP S PAGAG 33.78% HPRD:00969(in vivo)View