|Description: Cation-independent mannose-6-phosphate receptor precursor (CI Man-6-Preceptor) (CI-MPR) (M6PR) (Insulin-like growth factor 2 receptor)(Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2receptor) (M6P/IGF2R) (300 kDa mannose 6-phosphate receptor) (MPR 300)(MPR300) (CD222 antigen).|
Ensembl ID: ENSG00000197081
UniprotKB/SwissProt: MPRI_HUMAN (P11717)
Function: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Lysosome membrane; Single-pass type I membrane protein.