Regulatory Network in Protein Phosphorylation
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Substrate: IRS1

Description: Insulin receptor substrate 1 (IRS-1).

Ensembl ID: ENSG00000169047

UniprotKB/SwissProt: IRS1_HUMAN (P35568)

Function: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
PDB:1IRS
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of IRS1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1IRS1IRS1_HUMANS3---MA S PPESD 53.50% Swiss-Prot 55.0 (Similarity)View   
2IRS1IRS1_HUMANS24LRKPK S MHKRF 34.35%CK2_group Phospho.ELM 7.0 ViewAnalyzing
3IRS1IRS1_HUMANS24LRKPK S MHKRF 34.35%PLK1 Phospho.ELM 7.0  ViewAnalyzing
4IRS1IRS1_HUMANS24LRKPK S MHKRF 34.35%P67870(Casein kinase II, beta) HPRD:00943(in vitro) ViewAnalyzing
5IRS1IRS1_HUMANY46PARLE Y YENEK 22.22% Phospho.ELM 7.0View   
6IRS1IRS1_HUMANY46PARLE Y YENEK 22.22% Swiss-Prot 55.0 View   
7IRS1IRS1_HUMANT88LVALY T RDEHF 32.28%P67870(Casein kinase II, beta) HPRD:00943(in vitro) ViewAnalyzing
8IRS1IRS1_HUMANS99AIAAD S EAEQD 33.70%P67870(Casein kinase II, beta) HPRD:00943(in vitro) ViewAnalyzing
9IRS1IRS1_HUMANS99AIAAD S EAEQD 33.70%CK2_group Swiss-Prot 55.0 (Similarity) ViewAnalyzing
10IRS1IRS1_HUMANS268EFRPR S KSQSS 39.06%IKK_group Phospho.ELM 7.0 ViewAnalyzing
11IRS1IRS1_HUMANS268EFRPR S KSQSS 39.06%IKKb HPRD:00943(in vitro)  ViewAnalyzing
12IRS1IRS1_HUMANS270RPRSK S QSSSN 36.22%IKK_group Phospho.ELM 7.0 ViewAnalyzing
13IRS1IRS1_HUMANS270RPRSK S QSSSN 36.22%IKKb HPRD:00943(in vitro)  ViewAnalyzing
14IRS1IRS1_HUMANS272RSKSQ S SSNCS 42.71%IKKb HPRD:00943(in vitro)  ViewAnalyzing
15IRS1IRS1_HUMANS272RSKSQ S SSNCS 42.71%IKK_group Phospho.ELM 7.0 ViewAnalyzing
16IRS1IRS1_HUMANS274KSQSS S NCSNP 47.29%IKK_group Phospho.ELM 7.0 ViewAnalyzing
17IRS1IRS1_HUMANS274KSQSS S NCSNP 47.29%IKKb HPRD:00943(in vitro)  ViewAnalyzing
18IRS1IRS1_HUMANS307RSRTE S ITATS 25.32%IKK_group Phospho.ELM 7.0 ViewAnalyzing
19IRS1IRS1_HUMANS307RSRTE S ITATS 25.32%IKKb HPRD:00943(in vitro)  ViewAnalyzing
20IRS1IRS1_HUMANS307RSRTE S ITATS 25.32%PKCd(PKC delta) Phospho.ELM 7.0 ViewAnalyzing
21IRS1IRS1_HUMANS312SITAT S PASMV 18.92%JNK1 HPRD:00943(in vitro;in vivo)  ViewAnalyzing
22IRS1IRS1_HUMANS312SITAT S PASMV 18.92%MAPK_group Phospho.ELM 7.0 ViewAnalyzing
23IRS1IRS1_HUMANS312SITAT S PASMV 18.92%JNK1(MAPK8) Phospho.ELM 7.0 ViewAnalyzing
24IRS1IRS1_HUMANS312SITAT S PASMV 18.92% Swiss-Prot 55.0 (Similarity)View   
25IRS1IRS1_HUMANS312SITAT S PASMV 18.92%IKK_group Phospho.ELM 7.0 ViewAnalyzing
26IRS1IRS1_HUMANS312SITAT S PASMV 18.92%IKKb HPRD:00943(in vitro;in vivo)  ViewAnalyzing
27IRS1IRS1_HUMANS323GGKPG S FRVRA 20.57%PKCz(PKC zeta) Phospho.ELM 7.0 ViewAnalyzing
28IRS1IRS1_HUMANS329FRVRA S SDGEG 20.56% Swiss-Prot 55.0 (Similarity)View   
29IRS1IRS1_HUMANS330RVRAS S DGEGT 48.96%P67870(Casein kinase II, beta) HPRD:00943(in vitro) ViewAnalyzing
30IRS1IRS1_HUMANS341MSRPA S VDGSP 24.35%IKKb HPRD:00943(in vitro)  ViewAnalyzing
31IRS1IRS1_HUMANS341MSRPA S VDGSP 24.35%IKK_group Phospho.ELM 7.0 ViewAnalyzing
32IRS1IRS1_HUMANS345ASVDG S PVSPS 20.05%IKKb HPRD:00943(in vitro)  ViewAnalyzing
33IRS1IRS1_HUMANS345ASVDG S PVSPS 20.05%IKK_group Phospho.ELM 7.0 ViewAnalyzing
34IRS1IRS1_HUMANS345ASVDG S PVSPS 20.05% Swiss-Prot 55.0 (Similarity)View   
35IRS1IRS1_HUMANS348DGSPV S PSTNR 19.27% Phospho.ELM 7.0View   
36IRS1IRS1_HUMANS374LNHSR S IPMPA 33.77% Phospho.ELM 7.0View   
37IRS1IRS1_HUMANY465EELSN Y ICMGG 7.66%INSR Swiss-Prot 55.0 (Similarity)  ViewAnalyzing
38IRS1IRS1_HUMANT502GTGLG T SPALA 36.26%CK2a1-rs HPRD:00943(in vitro)  ViewAnalyzing
39IRS1IRS1_HUMANT502GTGLG T SPALA 36.26%CK2a1 HPRD:00943(in vitro)  ViewAnalyzing
40IRS1IRS1_HUMANS527RKRTH S AGTSP 27.99%IKK_group Phospho.ELM 7.0 ViewAnalyzing
41IRS1IRS1_HUMANS527RKRTH S AGTSP 27.99%IKKb HPRD:00943(in vitro)  ViewAnalyzing
42IRS1IRS1_HUMANT530THSAG T SPTIT 31.11% Phospho.ELM 7.0View   
43IRS1IRS1_HUMANS531HSAGT S PTITH 21.09%IKKb HPRD:00943(in vitro)  ViewAnalyzing
44IRS1IRS1_HUMANS531HSAGT S PTITH 21.09%IKK_group Phospho.ELM 7.0 ViewAnalyzing
45IRS1IRS1_HUMANS574PGHRH S AFVPT 24.29% HPRD:00943(in vitro)View   
46IRS1IRS1_HUMANS574PGHRH S AFVPT 24.29%PKCd(PKC delta) Phospho.ELM 7.0 ViewAnalyzing
47IRS1IRS1_HUMANY612HTDDG Y MPMSP 12.68%INSR Swiss-Prot 55.0 (Similarity)  ViewAnalyzing
48IRS1IRS1_HUMANY612HTDDG Y MPMSP 12.68%JAK1 HPRD:00943(in vitro;in vivo)  ViewAnalyzing
49IRS1IRS1_HUMANY612HTDDG Y MPMSP 12.68% HPRD:00943(in vivo)View   
50IRS1IRS1_HUMANY612HTDDG Y MPMSP 12.68% Phospho.ELM 7.0View   
51IRS1IRS1_HUMANS616GYMPM S PGVAP 16.78% HPRD:00943(in vivo)View   
52IRS1IRS1_HUMANS616GYMPM S PGVAP 16.78%Erk1(MAPK3) Phospho.ELM 7.0 ViewAnalyzing
53IRS1IRS1_HUMANS616GYMPM S PGVAP 16.78%Erk2 HPRD:00943(in vitro)  ViewAnalyzing
54IRS1IRS1_HUMANS629SGRKG S GDYMP 31.37% Swiss-Prot 55.0 View   
55IRS1IRS1_HUMANS629SGRKG S GDYMP 31.37% Phospho.ELM 7.0View   
56IRS1IRS1_HUMANS629SGRKG S GDYMP 31.37% HPRD:00943(in vitro)View   
57IRS1IRS1_HUMANY632KGSGD Y MPMSP 13.47%INSR Swiss-Prot 55.0 (Similarity)  ViewAnalyzing
58IRS1IRS1_HUMANY632KGSGD Y MPMSP 13.47%JAK1 HPRD:00943(in vitro;in vivo)  ViewAnalyzing
59IRS1IRS1_HUMANY632KGSGD Y MPMSP 13.47% Phospho.ELM 7.0View   
60IRS1IRS1_HUMANS636DYMPM S PKSVS 24.25% Phospho.ELM 7.0View   
61IRS1IRS1_HUMANS636DYMPM S PKSVS 24.25% Swiss-Prot 55.0 View   
62IRS1IRS1_HUMANS636DYMPM S PKSVS 24.25% HPRD:00943(in vivo)View   
63IRS1IRS1_HUMANS636DYMPM S PKSVS 24.25%Erk2 HPRD:00943(in vitro)  ViewAnalyzing
64IRS1IRS1_HUMANS639PMSPK S VSAPQ 25.37% Phospho.ELM 7.0View   
65IRS1IRS1_HUMANY662VDPNG Y MMMSP 6.62% Phospho.ELM 7.0View   
66IRS1IRS1_HUMANY662VDPNG Y MMMSP 6.62%JAK1 HPRD:00943(in vitro;in vivo)  ViewAnalyzing
67IRS1IRS1_HUMANY662VDPNG Y MMMSP 6.62% Swiss-Prot 55.0 View   
68IRS1IRS1_HUMANS666GYMMM S PSGGC 9.68% HPRD:00943(in vivo)View   
69IRS1IRS1_HUMANY732PCTGD Y MNMSP 7.54%JAK1 HPRD:00943(in vitro;in vivo)  ViewAnalyzing
70IRS1IRS1_HUMANS736DYMNM S PVGDS 16.07% HPRD:00943(in vivo)View   
71IRS1IRS1_HUMANS794LRLST S SGRLL 27.67%SIK Phospho.ELM 7.0  ViewAnalyzing
72IRS1IRS1_HUMANS794LRLST S SGRLL 27.67%NuaK2 Swiss-Prot 55.0   ViewAnalyzing
73IRS1IRS1_HUMANS794LRLST S SGRLL 27.67% HPRD:00943(in vitro;in vivo)View   
74IRS1IRS1_HUMANS794LRLST S SGRLL 27.67%QIK HPRD:00943(in vitro;in vivo)  ViewAnalyzing
75IRS1IRS1_HUMANT811DSSSS T SSDSL 33.91%P67870(Casein kinase II, beta) HPRD:00943(in vitro) ViewAnalyzing
76IRS1IRS1_HUMANS892PPEPK S PGEYV 49.18% Phospho.ELM 7.0View   
77IRS1IRS1_HUMANY896KSPGE Y VNIEF 12.52%IGF1R HPRD:00943(in vivo)  ViewAnalyzing
78IRS1IRS1_HUMANY896KSPGE Y VNIEF 12.52%INSR Swiss-Prot 55.0 (Similarity)  ViewAnalyzing
79IRS1IRS1_HUMANY896KSPGE Y VNIEF 12.52% HPRD:00943(in vivo)View   
80IRS1IRS1_HUMANY896KSPGE Y VNIEF 12.52% Phospho.ELM 7.0View   
81IRS1IRS1_HUMANY941TGTEE Y MKMDL 8.87% HPRD:00943(in vivo)View   
82IRS1IRS1_HUMANY941TGTEE Y MKMDL 8.87%INSR Swiss-Prot 55.0 (Similarity)  ViewAnalyzing
83IRS1IRS1_HUMANY989SSRGD Y MTMQM 9.41%INSR Swiss-Prot 55.0 (Similarity)  ViewAnalyzing
84IRS1IRS1_HUMANS1078TRVNL S PNRNQ 18.22% Phospho.ELM 7.0View   
85IRS1IRS1_HUMANS1101RRRHS S ETFSS 34.23%PKCg HPRD:00943(in vitro)  ViewAnalyzing
86IRS1IRS1_HUMANS1101RRRHS S ETFSS 34.23%PKCt(PKC theta) Phospho.ELM 7.0 ViewAnalyzing
87IRS1IRS1_HUMANS1101RRRHS S ETFSS 34.23%PKCd HPRD:00943(in vitro)  ViewAnalyzing
88IRS1IRS1_HUMANS1101RRRHS S ETFSS 34.23%PKCt HPRD:00943(in vitro;in vivo)  ViewAnalyzing
89IRS1IRS1_HUMANS1101RRRHS S ETFSS 34.23% Swiss-Prot 55.0 View   
90IRS1IRS1_HUMANS1145RHSSA S FENVW 34.73% Phospho.ELM 7.0View   
91IRS1IRS1_HUMANS1145RHSSA S FENVW 34.73% Swiss-Prot 55.0 (Similarity)View   
92IRS1IRS1_HUMANY1179ENGLN Y IDLDL 10.80%INSR Swiss-Prot 55.0 (Similarity)  ViewAnalyzing
93IRS1IRS1_HUMANY1179ENGLN Y IDLDL 10.80% HPRD:00943(in vivo)View   
94IRS1IRS1_HUMANS1222SSTRR S SEDLS 34.49% Phospho.ELM 7.0View   
95IRS1IRS1_HUMANS1223STRRS S EDLSA 33.06% Swiss-Prot 55.0 (Similarity)View   
96IRS1IRS1_HUMANS1223STRRS S EDLSA 33.06% Phospho.ELM 7.0View   
97IRS1IRS1_HUMANS1223STRRS S EDLSA 33.06% HPRD:00943(in vitro)View   
98IRS1IRS1_HUMANY1229EDLSA Y ASISF 9.48%INSR Swiss-Prot 55.0 (Similarity)  ViewAnalyzing
99IRS1IRS1_HUMANY1229EDLSA Y ASISF 9.48% HPRD:00943(in vivo)View