Regulatory Network in Protein Phosphorylation
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Substrate: LIG1

Description: DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotidesynthase [ATP] 1).

Ensembl ID: ENSG00000105486

UniprotKB/SwissProt: DNL1_HUMAN (P18858)

Function: This protein seals, during DNA replication, DNA recombination and DNA repair, nicks in double-stranded DNA.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
PDB:1X9N
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of LIG1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1LIG1DNL1_HUMANS47WNGVV S ESDSP 29.04% Phospho.ELM 7.0View   
2LIG1DNL1_HUMANS49GVVSE S DSPVK 35.56% Swiss-Prot 55.0 View   
3LIG1DNL1_HUMANS49GVVSE S DSPVK 35.56% Phospho.ELM 7.0View   
4LIG1DNL1_HUMANS51VSESD S PVKRP 40.65% Swiss-Prot 55.0 View   
5LIG1DNL1_HUMANS51VSESD S PVKRP 40.65% Phospho.ELM 7.0View   
6LIG1DNL1_HUMANS66ARVLG S EGEEE 37.96% Swiss-Prot 55.0 View   
7LIG1DNL1_HUMANS66ARVLG S EGEEE 37.96%CK2_group Phospho.ELM 7.0 ViewAnalyzing
8LIG1DNL1_HUMANS66ARVLG S EGEEE 37.96%CK2a1-rs HPRD:00534(in vivo)