|Description: Mitogen-activated protein kinase 9 (EC 188.8.131.52) (Stress-activatedprotein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).|
Synonyms: JNK2, PRKM9
Ensembl ID: ENSG00000050748
UniprotKB/SwissProt: MK09_HUMAN (P45984)
Function: Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T- cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. JNK2 isoforms display different binding patterns: alpha- 1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: