Regulatory Network in Protein Phosphorylation
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Substrate: MEF2A

Description: Myocyte-specific enhancer factor 2A (Serum response factor-likeprotein 1).

Synonyms: MEF2

Ensembl ID: ENSG00000068305

UniprotKB/SwissProt: MEF2A_HUMAN (Q02078)

Function: Transcription factor which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
PDB:1C7U
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of MEF2A

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1MEF2AMEF2A_HUMANS98HRGCD S PDPDT 34.97% Swiss-Prot 55.0 (Similarity)View   
2MEF2AMEF2A_HUMANT108TSYVL T PHTEE 11.72% Swiss-Prot 55.0 (Similarity)View   
3MEF2AMEF2A_HUMANS255VMPTK S PPPPG 45.15% Phospho.ELM 7.0View   
4MEF2AMEF2A_HUMANS289MMPPL S EEEEL 49.05%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
5MEF2AMEF2A_HUMANT312TQPLA T PVVSV 25.05%p38a(MAPK14) Phospho.ELM 7.0 ViewAnalyzing
6MEF2AMEF2A_HUMANT312TQPLA T PVVSV 25.05%Erk5 HPRD:02807(in vitro;in vivo)  ViewAnalyzing
7MEF2AMEF2A_HUMANT312TQPLA T PVVSV 25.05%Erk5(MAPK7) Phospho.ELM 7.0 ViewAnalyzing
8MEF2AMEF2A_HUMANT312TQPLA T PVVSV 25.05%p38a HPRD:02807(in vitro;in vivo)  ViewAnalyzing
9MEF2AMEF2A_HUMANT319VVSVT T PSLPP 14.55%p38a(MAPK14) Phospho.ELM 7.0 ViewAnalyzing
10MEF2AMEF2A_HUMANT319VVSVT T PSLPP 14.55%Erk5(MAPK7) Phospho.ELM 7.0 ViewAnalyzing
11MEF2AMEF2A_HUMANT319VVSVT T PSLPP 14.55%Erk5 HPRD:02807(in vitro;in vivo)  ViewAnalyzing
12MEF2AMEF2A_HUMANT319VVSVT T PSLPP 14.55%p38a HPRD:02807(in vitro;in vivo)  ViewAnalyzing
13MEF2AMEF2A_HUMANS355LQGFN S PGMLS 22.14%Erk5 HPRD:02807(in vitro;in vivo)  ViewAnalyzing
14MEF2AMEF2A_HUMANS355LQGFN S PGMLS 22.14%Erk5(MAPK7) Phospho.ELM 7.0 ViewAnalyzing
15MEF2AMEF2A_HUMANS408KSEPI S PPRDR 39.30%CDK5 HPRD:02807(in vitro;in vivo)  ViewAnalyzing
16MEF2AMEF2A_HUMANS408KSEPI S PPRDR 39.30%CDK5 Phospho.ELM 7.0  ViewAnalyzing
17MEF2AMEF2A_HUMANS408KSEPI S PPRDR 39.30%p38a(MAPK14) Phospho.ELM 7.0 ViewAnalyzing
18MEF2AMEF2A_HUMANS408KSEPI S PPRDR 39.30% Swiss-Prot 55.0 View   
19MEF2AMEF2A_HUMANS453QEMGR S PVDSL 24.44%p38a(MAPK14) Phospho.ELM 7.0 ViewAnalyzing
20MEF2AMEF2A_HUMANS453QEMGR S PVDSL 24.44%p38a HPRD:02807(in vitro;in vivo)  ViewAnalyzing