Regulatory Network in Protein Phosphorylation
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Substrate: MYC

Description: Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

Ensembl ID: ENSG00000136997

UniprotKB/SwissProt: MYC_HUMAN (P01106)

Function: Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
PDB:1A93
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of MYC

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1MYCMYC_HUMANT8LNVSF T NRNYD 26.26%RAF_group Swiss-Prot 55.0 (in vitro) ViewAnalyzing
2MYCMYC_HUMANT58FELLP T PPLSP 37.19%GSK3A(GSK3 alpha) Phospho.ELM 7.0 ViewAnalyzing
3MYCMYC_HUMANT58FELLP T PPLSP 37.19%GSK3B HPRD:01818(in vivo)  ViewAnalyzing
4MYCMYC_HUMANT58FELLP T PPLSP 37.19%GSK3B(GSK3 beta) Phospho.ELM 7.0 ViewAnalyzing
5MYCMYC_HUMANT58FELLP T PPLSP 37.19%GSK_group Phospho.ELM 7.0 ViewAnalyzing
6MYCMYC_HUMANT58FELLP T PPLSP 37.19%CK2a2 HPRD:01818(in vivo)  ViewAnalyzing
7MYCMYC_HUMANT58FELLP T PPLSP 37.19%CK2a1-rs HPRD:01818(in vivo)  ViewAnalyzing
8MYCMYC_HUMANT58FELLP T PPLSP 37.19%CK2a1 HPRD:01818(in vivo)  ViewAnalyzing
9MYCMYC_HUMANT58FELLP T PPLSP 37.19% Swiss-Prot 55.0 View   
10MYCMYC_HUMANS62PTPPL S PSRRS 26.97%JNK1 HPRD:01818(in vivo)  ViewAnalyzing
11MYCMYC_HUMANS62PTPPL S PSRRS 26.97%Erk2(MAPK1) Phospho.ELM 7.0 ViewAnalyzing
12MYCMYC_HUMANS62PTPPL S PSRRS 26.97% Swiss-Prot 55.0 View   
13MYCMYC_HUMANS71RSGLC S PSYVA 23.17%JNK1 HPRD:01818(in vitro)  ViewAnalyzing