Regulatory Network in Protein Phosphorylation
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Substrate: PACS1

Description: Phosphofurin acidic cluster sorting protein 1 (PACS-1).

Synonyms: KIAA1175

Ensembl ID: ENSG00000175115

UniprotKB/SwissProt: PACS1_HUMAN (Q6VY07)

Function: Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin- coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Golgi apparatus, trans-Golgi network (By similarity). Note=Localizes in the perinuclear region, probably the TGN (By similarity).
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PACS1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PACS1PACS1_HUMANS28SGVAQ S PQQPP 18.22% Swiss-Prot 55.0 (Similarity)View   
2PACS1PACS1_HUMANT46PPQQP T PPKLA 48.13% Phospho.ELM 7.0View   
3PACS1PACS1_HUMANT46PPQQP T PPKLA 48.13% HPRD:06320(in vivo)View   
4PACS1PACS1_HUMANT46PPQQP T PPKLA 48.13% Swiss-Prot 55.0 View   
5PACS1PACS1_HUMANY251AEIKI Y SLSSQ 9.88% Swiss-Prot 55.0 (Similarity)View   
6PACS1PACS1_HUMANS278DIDNY S EEEEE 44.80%CK2a1 HPRD:06320(in vitro;in vivo)  ViewAnalyzing
7PACS1PACS1_HUMANS278DIDNY S EEEEE 44.80%CK2a1-rs HPRD:06320(in vitro;in vivo)  ViewAnalyzing
8PACS1PACS1_HUMANS278DIDNY S EEEEE 44.80%CK2_group Phospho.ELM 7.0 ViewAnalyzing
9PACS1PACS1_HUMANS407FFEGM S QSSSQ 37.45% Swiss-Prot 55.0 View   
10PACS1PACS1_HUMANS410GMSQS S SQTEI 20.87% Swiss-Prot 55.0 View   
11PACS1PACS1_HUMANT429LGKDT T SPMEL 40.75% Swiss-Prot 55.0 (Similarity)View