Regulatory Network in Protein Phosphorylation
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Substrate: PPP1R8

Description: Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Proteinphosphatase 1 regulatory inhibitor subunit 8) [Includes: Activator ofRNA decay (EC 3.1.4.-) (ARD-1)].

Synonyms: ARD1, NIPP1

Ensembl ID: ENSG00000117751

UniprotKB/SwissProt: PP1R8_HUMAN (Q12972)

Function: Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation. Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Nucleus speckle. Note=Primarily, but not exclusively, nuclear. Isoform Gamma: Cytoplasm. Note=Found mainly in the cytoplasm.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PPP1R8

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PPP1R8PP1R8_HUMANT161LPEEE T ELDNL 45.16%CK2a1-rs HPRD:04028(in vitro)  ViewAnalyzing
2PPP1R8PP1R8_HUMANT161LPEEE T ELDNL 45.16%CK2a1 HPRD:04028(in vitro)  ViewAnalyzing
3PPP1R8PP1R8_HUMANT161LPEEE T ELDNL 45.16%CK2_group Phospho.ELM 7.0 ViewAnalyzing
4PPP1R8PP1R8_HUMANT161LPEEE T ELDNL 45.16%CK2a2 HPRD:04028(in vitro)  ViewAnalyzing
5PPP1R8PP1R8_HUMANS178HNKRI S TLTIE 22.77%PKACa HPRD:04028(in vitro)  ViewAnalyzing
6PPP1R8PP1R8_HUMANS178HNKRI S TLTIE 22.77%PKA_group Phospho.ELM 7.0 ViewAnalyzing
7PPP1R8PP1R8_HUMANS199RKRKN S RVTFS 31.03%PKA_group Phospho.ELM 7.0 ViewAnalyzing
8PPP1R8PP1R8_HUMANS199RKRKN S RVTFS 31.03% Swiss-Prot 55.0 (Similarity)View   
9PPP1R8PP1R8_HUMANS199RKRKN S RVTFS 31.03%PKACa HPRD:04028(in vitro)  ViewAnalyzing
10PPP1R8PP1R8_HUMANS204SRVTF S EDDEI 30.65%CK2a1 HPRD:04028(in vitro)  ViewAnalyzing
11PPP1R8PP1R8_HUMANS204SRVTF S EDDEI 30.65%CK2_group Phospho.ELM 7.0 ViewAnalyzing
12PPP1R8PP1R8_HUMANS204SRVTF S EDDEI 30.65%CK2a2 HPRD:04028(in vitro)  ViewAnalyzing
13PPP1R8PP1R8_HUMANS204SRVTF S EDDEI 30.65%CK2a1-rs HPRD:04028(in vitro)  ViewAnalyzing
14PPP1R8PP1R8_HUMANS204SRVTF S EDDEI 30.65% Swiss-Prot 55.0 (Similarity)View   
15PPP1R8PP1R8_HUMANY264FSGGL Y GGLPP 16.66%LYN Swiss-Prot 55.0 (in vitro)  ViewAnalyzing
16PPP1R8PP1R8_HUMANY264FSGGL Y GGLPP 16.66%Lyn Phospho.ELM 7.0  ViewAnalyzing
17PPP1R8PP1R8_HUMANY264FSGGL Y GGLPP 16.66%LYN HPRD:04028(in vitro)  ViewAnalyzing
18PPP1R8PP1R8_HUMANY335PKKKK Y AKEAW 31.61% Swiss-Prot 55.0 (Probable)View   
19PPP1R8PP1R8_HUMANY335PKKKK Y AKEAW 31.61%LYN HPRD:04028(in vitro)  ViewAnalyzing
20PPP1R8PP1R8_HUMANY335PKKKK Y AKEAW 31.61%Lyn Phospho.ELM 7.0  ViewAnalyzing