|Description: Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Proteinphosphatase 1 regulatory inhibitor subunit 8) [Includes: Activator ofRNA decay (EC 3.1.4.-) (ARD-1)].|
Synonyms: ARD1, NIPP1
Ensembl ID: ENSG00000117751
UniprotKB/SwissProt: PP1R8_HUMAN (Q12972)
Function: Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation. Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Nucleus speckle. Note=Primarily, but not exclusively, nuclear. Isoform Gamma: Cytoplasm. Note=Found mainly in the cytoplasm.