Regulatory Network in Protein Phosphorylation
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Substrate: PTEN

Description: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16)(EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multipleadvanced cancers 1).

Synonyms: MMAC1, TEP1

Ensembl ID: ENSG00000171862

UniprotKB/SwissProt: PTEN_HUMAN (P60484)

Function: Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3- phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K- AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.
PDB:1D5R
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PTEN

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PTENPTEN_HUMANS229IYSSN S GPTRR 48.36%ROCK1 Phospho.ELM 7.0  ViewAnalyzing
2PTENPTEN_HUMANT232SNSGP T RREDK 45.97%ROCK1 Phospho.ELM 7.0  ViewAnalyzing
3PTENPTEN_HUMANY240EDKFM Y FEFPQ 11.77% HPRD:03431(in vitro)View   
4PTENPTEN_HUMANY240EDKFM Y FEFPQ 11.77%Lck Phospho.ELM 7.0  ViewAnalyzing
5PTENPTEN_HUMANY315DNDKE Y LVLTL 14.09% HPRD:03431(in vitro)View   
6PTENPTEN_HUMANY315DNDKE Y LVLTL 14.09%Lck