|Description: Leukocyte common antigen precursor (EC 220.127.116.11) (L-CA) (T200) (CD45antigen).|
Ensembl ID: ENSG00000081237
UniprotKB/SwissProt: CD45_HUMAN (P08575)
Function: Required for T-cell activation through the antigen receptor. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits an dephosphorylates SKAP1 and FYN.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane; Single-pass type I membrane protein.