Regulatory Network in Protein Phosphorylation
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Substrate: RELA

Description: Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit).

Synonyms: NFKB3

Ensembl ID: ENSG00000173039

UniprotKB/SwissProt: TF65_HUMAN (Q04206)

Function: p65 is a subunit of the nuclear factor kappa-B, a second messenger, which activates the transcription of a number of genes in multiple tissues. The inhibitory effect of I-kappa-B upon NF- kappa-B in the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of RELA

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1RELATF65_HUMANT254AIVFR T PPYAD 19.70% Phospho.ELM 7.0View   
2RELATF65_HUMANS276QLRRP S DRELS 47.70%MSK2 Swiss-Prot 55.0   ViewAnalyzing
3RELATF65_HUMANS276QLRRP S DRELS 47.70%MSK1 Swiss-Prot 55.0   ViewAnalyzing
4RELATF65_HUMANS276QLRRP S DRELS 47.70%PKACa HPRD:01241(in vitro;in vivo)  ViewAnalyzing
5RELATF65_HUMANS276QLRRP S DRELS 47.70%MSK1(RSK5) Phospho.ELM 7.0 ViewAnalyzing
6RELATF65_HUMANS311YETFK S IMKKS 24.59%PKCz HPRD:01241(in vitro;in vivo)  ViewAnalyzing
7RELATF65_HUMANS311YETFK S IMKKS 24.59%PKCz(PKC zeta) Phospho.ELM 7.0 ViewAnalyzing
8RELATF65_HUMANT435QAGEG T LSEAL 23.86%Erk2(MAPK1) Phospho.ELM 7.0 ViewAnalyzing
9RELATF65_HUMANS468FTDLA S VDNSE 36.98%GSK3B(GSK3 beta) Phospho.ELM 7.0 ViewAnalyzing
10RELATF65_HUMANT505ITRLV T GAQRP 31.24% Phospho.ELM 7.0