Regulatory Network in Protein Phosphorylation
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Substrate: SERPINF1

Description: Pigment epithelium-derived factor precursor (PEDF) (Serpin-F1) (EPC-1).

Synonyms: PEDF

Ensembl ID: ENSG00000132386

UniprotKB/SwissProt: PEDF_HUMAN (P36955)

Function: Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Secreted. Melanosome. Note=Enriched in stage I melanosomes.
PDB:1IMV
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of SERPINF1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1SERPINF1PEDF_HUMANS24CQNPA S PPEEG 42.09%CK2_group Swiss-Prot 55.0  ViewAnalyzing
2SERPINF1PEDF_HUMANS114YYDLI S SPDIH 43.02%CK2_group Swiss-Prot 55.0  ViewAnalyzing
3SERPINF1PEDF_HUMANS227DSRKT S LEDFY 32.56%PKA_group Swiss-Prot 55.0  ViewAnalyzing