|Description: Pigment epithelium-derived factor precursor (PEDF) (Serpin-F1) (EPC-1).|
Ensembl ID: ENSG00000132386
UniprotKB/SwissProt: PEDF_HUMAN (P36955)
Function: Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted. Melanosome. Note=Enriched in stage I melanosomes.