Regulatory Network in Protein Phosphorylation
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Substrate: SLC18A2

Description: Synaptic vesicular amine transporter (Monoamine transporter)(Vesicular amine transporter 2) (VAT2) (Solute carrier family 18member 2).

Synonyms: SVMT, VMAT2

Ensembl ID: ENSG00000165646

UniprotKB/SwissProt: VMAT2_HUMAN (Q05940)

Function: Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of SLC18A2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1SLC18A2VMAT2_HUMANS511GEDEE S ESD 40.11%CK2_group Swiss-Prot 55.0 (Similarity) ViewAnalyzing
2SLC18A2VMAT2_HUMANS511GEDEE S ESD 40.11%CK2_group Phospho.ELM 7.0 ViewAnalyzing
3SLC18A2VMAT2_HUMANS511GEDEE S ESD 40.11%CK1a HPRD:01896(in vitro)  ViewAnalyzing
4SLC18A2VMAT2_HUMANS511GEDEE S ESD 40.11%CK2a1 HPRD:01896(in vitro)  ViewAnalyzing
5SLC18A2VMAT2_HUMANS511GEDEE S ESD 40.11%CK1_group Phospho.ELM 7.0 ViewAnalyzing
6SLC18A2VMAT2_HUMANS511GEDEE S ESD 40.11%CK2a2 HPRD:01896(in vitro)  ViewAnalyzing
7SLC18A2VMAT2_HUMANS511GEDEE S ESD 40.11%CK2a1-rs HPRD:01896(in vitro)  ViewAnalyzing
8SLC18A2VMAT2_HUMANS513DEESE S58.88%CK2_group Phospho.ELM 7.0 ViewAnalyzing
9SLC18A2VMAT2_HUMANS513DEESE S58.88%CK2_group Swiss-Prot 55.0 (Similarity) ViewAnalyzing
10SLC18A2VMAT2_HUMANS513DEESE S58.88%CK1_group Phospho.ELM 7.0 ViewAnalyzing