Ensembl ID: ENSG00000074317
UniprotKB/SwissProt: SYUB_HUMAN (Q16143)
Function: Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6 hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm.