Regulatory Network in Protein Phosphorylation
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Substrate: SNCB

Description: Beta-synuclein.

Ensembl ID: ENSG00000074317

UniprotKB/SwissProt: SYUB_HUMAN (Q16143)

Function: Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6 hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of SNCB

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1SNCBSYUB_HUMANS118EPEGE S YEDPP 44.68%CK2_group Swiss-Prot 55.0  ViewAnalyzing
2SNCBSYUB_HUMANS118EPEGE S YEDPP 44.68%GPRK5(GRK5) Swiss-Prot 55.0  ViewAnalyzing
3SNCBSYUB_HUMANS118EPEGE S YEDPP 44.68%BARK1 Swiss-Prot 55.0   ViewAnalyzing
4SNCBSYUB_HUMANS118EPEGE S YEDPP 44.68%GPRK5 HPRD:03980(in vitro)  ViewAnalyzing