|Description: Gamma-synuclein (Persyn) (Breast cancer-specific gene 1 protein)(Synoretin) (SR).|
Synonyms: BCSG1, PERSYN, PRSN
Ensembl ID: ENSG00000173267
UniprotKB/SwissProt: SYUG_HUMAN (O76070)
Function: Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, perinuclear region. Centrosome. Spindle. Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.