Regulatory Network in Protein Phosphorylation
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Substrate: SNCG

Description: Gamma-synuclein (Persyn) (Breast cancer-specific gene 1 protein)(Synoretin) (SR).

Synonyms: BCSG1, PERSYN, PRSN

Ensembl ID: ENSG00000173267

UniprotKB/SwissProt: SYUG_HUMAN (O76070)

Function: Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, perinuclear region. Centrosome. Spindle. Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of SNCG

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1SNCGSYUG_HUMANS124AEEAQ S GGD 52.36%CK2_group Swiss-Prot 55.0  ViewAnalyzing
2SNCGSYUG_HUMANS124AEEAQ S GGD 52.36%BARK1 Swiss-Prot 55.0   ViewAnalyzing
3SNCGSYUG_HUMANS124AEEAQ S GGD 52.36%CaMK2_group Swiss-Prot 55.0  ViewAnalyzing
4SNCGSYUG_HUMANS124AEEAQ S GGD 52.36%GPRK5 HPRD:04297(in vitro)  ViewAnalyzing