Regulatory Network in Protein Phosphorylation
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Substrate: SPIB

Description: Transcription factor Spi-B.

Ensembl ID: ENSG00000142539

UniprotKB/SwissProt: SPIB_HUMAN (Q01892)

Function: Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Isoform 1: Nucleus. Isoform 2: Cytoplasm.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of SPIB

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1SPIBSPIB_HUMANS37SSYPD S EGAPD 33.16%CK2_group Phospho.ELM 7.0 ViewAnalyzing
2SPIBSPIB_HUMANS37SSYPD S EGAPD 33.16%CK2a1 HPRD:06007(in vitro;in vivo)  ViewAnalyzing
3SPIBSPIB_HUMANS37SSYPD S EGAPD 33.16%CK2a1-rs HPRD:06007(in vitro;in vivo)  ViewAnalyzing
4SPIBSPIB_HUMANS37SSYPD S EGAPD 33.16%CK2a2 HPRD:06007(in vitro;in vivo)  ViewAnalyzing
5SPIBSPIB_HUMANT56PPVPA T PYEAF 21.97%Erk1(MAPK3) Phospho.ELM 7.0 ViewAnalyzing
6SPIBSPIB_HUMANT56PPVPA T PYEAF 21.97%Erk1 HPRD:06007(in vitro)  ViewAnalyzing
7SPIBSPIB_HUMANS129PSPVL S EEEDL 43.10%CK2a2 HPRD:06007(in vitro;in vivo)  ViewAnalyzing
8SPIBSPIB_HUMANS129PSPVL S EEEDL 43.10%CK2_group Phospho.ELM 7.0 ViewAnalyzing
9SPIBSPIB_HUMANS129PSPVL S EEEDL 43.10%CK2a1-rs HPRD:06007(in vitro;in vivo)  ViewAnalyzing
10SPIBSPIB_HUMANS129PSPVL S EEEDL 43.10%CK2a1 HPRD:06007(in vitro;in vivo)  ViewAnalyzing
11SPIBSPIB_HUMANS144PALEV S DSESD 26.50%CK2a1 HPRD:06007(in vitro;in vivo)  ViewAnalyzing
12SPIBSPIB_HUMANS144PALEV S DSESD 26.50%CK2_group Phospho.ELM 7.0 ViewAnalyzing
13SPIBSPIB_HUMANS144PALEV S DSESD 26.50%CK2a2 HPRD:06007(in vitro;in vivo)  ViewAnalyzing
14SPIBSPIB_HUMANS144PALEV S DSESD 26.50%CK2a1-rs HPRD:06007(in vitro;in vivo)  ViewAnalyzing
15SPIBSPIB_HUMANS146LEVSD S ESDEA 31.34%CK2a2 HPRD:06007(in vitro;in vivo)  ViewAnalyzing
16SPIBSPIB_HUMANS146LEVSD S ESDEA 31.34%CK2_group Phospho.ELM 7.0 ViewAnalyzing
17SPIBSPIB_HUMANS146LEVSD S ESDEA 31.34%CK2a1 HPRD:06007(in vitro;in vivo)  ViewAnalyzing
18SPIBSPIB_HUMANS146LEVSD S ESDEA 31.34%CK2a1-rs HPRD:06007(in vitro;in vivo)  ViewAnalyzing