Regulatory Network in Protein Phosphorylation
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Substrate: SRF

Description: Serum response factor (SRF).

Ensembl ID: ENSG00000112658

UniprotKB/SwissProt: SRF_HUMAN (P11831)

Function: SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentation and maturation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
PDB:1HBX
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of SRF

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1SRFSRF_HUMANY76TAGAL Y SGSEG 15.51% Swiss-Prot 55.0 View   
2SRFSRF_HUMANS77AGALY S GSEGD 36.37% Swiss-Prot 55.0 View   
3SRFSRF_HUMANS77AGALY S GSEGD 36.37%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
4SRFSRF_HUMANS79ALYSG S EGDSE 32.25%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
5SRFSRF_HUMANS79ALYSG S EGDSE 32.25% Swiss-Prot 55.0 View   
6SRFSRF_HUMANS83GSEGD S ESGEE 44.51%CK2a1 HPRD:02788(in vitro)  ViewAnalyzing
7SRFSRF_HUMANS83GSEGD S ESGEE 44.51%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
8SRFSRF_HUMANS83GSEGD S ESGEE 44.51% Swiss-Prot 55.0 View   
9SRFSRF_HUMANS83GSEGD S ESGEE 44.51%CK2a1-rs HPRD:02788(in vitro)  ViewAnalyzing
10SRFSRF_HUMANS85EGDSE S GEEEE 56.29% Swiss-Prot 55.0 View   
11SRFSRF_HUMANS85EGDSE S GEEEE 56.29%MAPKAPK2 Phospho.ELM 7.0  ViewAnalyzing
12SRFSRF_HUMANS103LKRSL S EMEIG 35.82%MAPKAPK2 HPRD:02788(in vitro;in vivo)  ViewAnalyzing
13SRFSRF_HUMANS103LKRSL S EMEIG 35.82%RSK3 HPRD:02788(in vitro;in vivo)  ViewAnalyzing
14SRFSRF_HUMANS103LKRSL S EMEIG 35.82%RSK_group Phospho.ELM 7.0 ViewAnalyzing
15SRFSRF_HUMANS103LKRSL S EMEIG 35.82%CaMK2a HPRD:02788(in vitro;in vivo)  ViewAnalyzing
16SRFSRF_HUMANS103LKRSL S EMEIG 35.82% Swiss-Prot 55.0 View   
17SRFSRF_HUMANT159KLRRY T TFSKR 21.39%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing
18SRFSRF_HUMANT159KLRRY T TFSKR 21.39%DMPK_group Phospho.ELM 7.0 ViewAnalyzing
19SRFSRF_HUMANT160LRRYT T FSKRK 19.58%CaMK2a HPRD:02788(in vitro)  ViewAnalyzing
20SRFSRF_HUMANS224LNSPD S PPRSD 39.94% Swiss-Prot 55.0 View   
21SRFSRF_HUMANS224LNSPD S PPRSD 39.94% Phospho.ELM 7.0View   
22SRFSRF_HUMANS253YQVSE S DSSGE 34.97% Swiss-Prot 55.0 View   
23SRFSRF_HUMANS435VLNAF S QAPST 24.03%DNAPK HPRD:02788(in vitro;in vivo)  ViewAnalyzing
24SRFSRF_HUMANS435VLNAF S QAPST 24.03%DNAPK Phospho.ELM 7.0  ViewAnalyzing
25SRFSRF_HUMANS435VLNAF S QAPST 24.03%DNAPK Swiss-Prot 55.0   ViewAnalyzing
26SRFSRF_HUMANS446MQVSH S QVQEP 25.25%DNAPK HPRD:02788(in vitro;in vivo)  ViewAnalyzing
27SRFSRF_HUMANS446MQVSH S QVQEP 25.25%DNAPK Phospho.ELM 7.0  ViewAnalyzing
28SRFSRF_HUMANS446MQVSH S QVQEP 25.25%DNAPK Swiss-Prot 55.0   ViewAnalyzing