Regulatory Network in Protein Phosphorylation
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Substrate: SRPK1

Description: Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRSprotein kinase 1).

Ensembl ID: ENSG00000096063

UniprotKB/SwissProt: SRPK1_HUMAN (Q96SB4)

Function: Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Hyperphosphorylates RS domain-containing proteins such as SFRS1 and SFRS2 on serine residues during metaphase but at lower levels during interphase. Locks onto SFRS1 to form a stable complex and processively phosphorylates the RS domain. Appears to mediate HBV core protein phosphorylation which is a prerequisite for pregenomic RNA encapsidation into viral capsids.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Isoform 1 and isoform 2 are cytoplasmic and nuclear.
PDB:1WAK
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of SRPK1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1SRPK1SRPK1_HUMANS222EEILG S DDDEQ 34.13%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
2SRPK1SRPK1_HUMANS222EEILG S DDDEQ 34.13%CK2_group Swiss-Prot 55.0  ViewAnalyzing
3SRPK1SRPK1_HUMANS222EEILG S DDDEQ 34.13%CK2 beta Phospho.ELM 7.0 ViewAnalyzing
4SRPK1SRPK1_HUMANS480NKQEE S ESPVE 42.49% Swiss-Prot 55.0 View   
5SRPK1SRPK1_HUMANS480NKQEE S ESPVE 42.49% Phospho.ELM 7.0View   
6SRPK1SRPK1_HUMANS482QEESE S PVERP 43.45% Phospho.ELM 7.0View   
7SRPK1SRPK1_HUMANS482QEESE S PVERP 43.45% Swiss-Prot 55.0 View   
8SRPK1SRPK1_HUMANS726LFEPH S GEEYT 59.63%CK2_group Swiss-Prot 55.0  ViewAnalyzing
9SRPK1SRPK1_HUMANS726LFEPH S GEEYT 59.63%CK2 beta Phospho.ELM 7.0 ViewAnalyzing
10SRPK1SRPK1_HUMANS726LFEPH S GEEYT 59.63%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing