Regulatory Network in Protein Phosphorylation
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Substrate: SSB

Description: Lupus La protein (Sjoegren syndrome type B antigen) (SS-B) (Laribonucleoprotein) (La autoantigen).

Ensembl ID: ENSG00000138385

UniprotKB/SwissProt: LA_HUMAN (P05455)

Function: La protein plays a role in the transcription of RNA polymerase III. It is most probably a transcription termination factor. Binds to the 3' termini of virtually all nascent polymerase III transcripts. It is associated with precursor forms of RNA polymerase III transcripts including tRNA and 4.5S, 5S, 7S, and 7-2 RNAs.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus (Probable).
PDB:1OWX
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of SSB

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1SSBLA_HUMANT302RNKEV T WEVLE 19.59% HPRD:00168(in vitro)View   
2SSBLA_HUMANT302RNKEV T WEVLE 19.59% Phospho.ELM 7.0View   
3SSBLA_HUMANS325EDQQE S LNKWK 32.67% Phospho.ELM 7.0View   
4SSBLA_HUMANS325EDQQE S LNKWK 32.67% HPRD:00168(in vitro)View   
5SSBLA_HUMANT362FQGKK T KFASD 34.58% HPRD:00168(in vitro)View   
6SSBLA_HUMANT362FQGKK T KFASD 34.58% Phospho.ELM 7.0View   
7SSBLA_HUMANS366KTKFA S DDEHD 49.04%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
8SSBLA_HUMANS366KTKFA S DDEHD 49.04% HPRD:00168(in vitro)View   
9SSBLA_HUMANS366KTKFA S DDEHD 49.04%CK2_group Phospho.ELM 7.0 ViewAnalyzing
10SSBLA_HUMANS366KTKFA S DDEHD 49.04%CK2_group Swiss-Prot 55.0  ViewAnalyzing