Regulatory Network in Protein Phosphorylation
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Substrate: SUB1

Description: Activated RNA polymerase II transcriptional coactivator p15 (SUB1homolog) (Positive cofactor 4) (PC4) (p14).

Synonyms: PC4, RPO2TC1

Ensembl ID: ENSG00000113387

UniprotKB/SwissProt: TCP4_HUMAN (P53999)

Function: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
PDB:1PCF
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of SUB1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1SUB1TCP4_HUMANS9SKELV S SSSSG 36.81% Swiss-Prot 55.0 View   
2SUB1TCP4_HUMANS9SKELV S SSSSG 36.81%CK2a1-rs HPRD:02737(in vitro;in vivo)  ViewAnalyzing
3SUB1TCP4_HUMANS9SKELV S SSSSG 36.81%CK2a1 HPRD:02737(in vitro;in vivo)  ViewAnalyzing
4SUB1TCP4_HUMANS10KELVS S SSSGS 27.10% Swiss-Prot 55.0 View   
5SUB1TCP4_HUMANS10KELVS S SSSGS 27.10%CK2a1-rs HPRD:02737(in vitro;in vivo)  ViewAnalyzing
6SUB1TCP4_HUMANS10KELVS S SSSGS 27.10%CK2a1 HPRD:02737(in vitro;in vivo)  ViewAnalyzing
7SUB1TCP4_HUMANS11ELVSS S SSGSD 22.48%CK2_group Phospho.ELM 7.0 ViewAnalyzing
8SUB1TCP4_HUMANS11ELVSS S SSGSD 22.48% Swiss-Prot 55.0 View   
9SUB1TCP4_HUMANS12LVSSS S SGSDS 40.44%CK2a1-rs HPRD:02737(in vitro;in vivo)  ViewAnalyzing
10SUB1TCP4_HUMANS12LVSSS S SGSDS 40.44% Swiss-Prot 55.0 View   
11SUB1TCP4_HUMANS12LVSSS S SGSDS 40.44%CK2a1 HPRD:02737(in vitro;in vivo)  ViewAnalyzing
12SUB1TCP4_HUMANS13VSSSS S GSDSD 44.24%CK2a1-rs HPRD:02737(in vitro;in vivo)  ViewAnalyzing
13SUB1TCP4_HUMANS13VSSSS S GSDSD 44.24%CK2_group Phospho.ELM 7.0 ViewAnalyzing
14SUB1TCP4_HUMANS13VSSSS S GSDSD 44.24%CK2a1 HPRD:02737(in vitro;in vivo)  ViewAnalyzing
15SUB1TCP4_HUMANS13VSSSS S GSDSD 44.24% Swiss-Prot 55.0 View   
16SUB1TCP4_HUMANS15SSSSG S DSDSE 35.57% Swiss-Prot 55.0 View   
17SUB1TCP4_HUMANS15SSSSG S DSDSE 35.57%CK2_group Phospho.ELM 7.0 ViewAnalyzing
18SUB1TCP4_HUMANS15SSSSG S DSDSE 35.57%CK2a1-rs HPRD:02737(in vitro;in vivo)  ViewAnalyzing
19SUB1TCP4_HUMANS15SSSSG S DSDSE 35.57%CK2a1 HPRD:02737(in vitro;in vivo)  ViewAnalyzing
20SUB1TCP4_HUMANS17SSGSD S DSEVD 44.74%CK2a1-rs HPRD:02737(in vitro;in vivo)  ViewAnalyzing
21SUB1TCP4_HUMANS17SSGSD S DSEVD 44.74%CK2a1 HPRD:02737(in vitro;in vivo)  ViewAnalyzing
22SUB1TCP4_HUMANS17SSGSD S DSEVD 44.74%CK2_group Phospho.ELM 7.0 ViewAnalyzing
23SUB1TCP4_HUMANS17SSGSD S DSEVD 44.74% Swiss-Prot 55.0 View   
24SUB1TCP4_HUMANS17SSGSD S DSEVD 44.74% HPRD:02737(in vivo)View   
25SUB1TCP4_HUMANS19GSDSD S EVDKK 43.39% HPRD:02737(in vivo)View   
26SUB1TCP4_HUMANS19GSDSD S EVDKK 43.39%CK2a1-rs HPRD:02737(in vitro;in vivo)  ViewAnalyzing
27SUB1TCP4_HUMANS19GSDSD S EVDKK 43.39%CK2_group Phospho.ELM 7.0 ViewAnalyzing
28SUB1TCP4_HUMANS19GSDSD S EVDKK 43.39% Swiss-Prot 55.0 View   
29SUB1TCP4_HUMANS19GSDSD S EVDKK 43.39%CK2a1 HPRD:02737(in vitro;in vivo)  ViewAnalyzing
30SUB1TCP4_HUMANS50TSRAL S SSKQS 31.42% Swiss-Prot 55.0 View   
31SUB1TCP4_HUMANS52RALSS S KQSSS 31.19% Swiss-Prot 55.0 View   
32SUB1TCP4_HUMANS56SSKQS S SSRDD 29.82% Swiss-Prot 55.0 View   
33SUB1TCP4_HUMANS58KQSSS S RDDNM 41.50% Swiss-Prot 55.0 View