Regulatory Network in Protein Phosphorylation
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Substrate: TCF4

Description: Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2)(SL3-3 enhancer factor 2) (SEF-2).

Synonyms: ITF2, SEF2

Ensembl ID: ENSG00000196628

UniprotKB/SwissProt: ITF2_HUMAN (P15884)

Function: Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'- ACANNTGT-3' or 5'-CCANNTGG-3'.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus (Probable).
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of TCF4

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1TCF4ITF2_HUMANS54NVEDR S SSGSW 40.97%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
2TCF4ITF2_HUMANS55VEDRS S SGSWG 39.34%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
3TCF4ITF2_HUMANS56EDRSS S GSWGN 37.79%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing