Regulatory Network in Protein Phosphorylation
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Substrate: TFPI

Description: Tissue factor pathway inhibitor precursor (TFPI) (Lipoprotein-associated coagulation inhibitor) (LACI) (Extrinsic pathway inhibitor)(EPI).

Synonyms: LACI, TFPI1

Ensembl ID: ENSG00000003436

UniprotKB/SwissProt: TFPI1_HUMAN (P10646)

Function: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Secreted.
PDB:1ADZ
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of TFPI

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1TFPITFPI1_HUMANS30PLNAD S EEDEE 40.24%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing