|Description: Tumor necrosis factor precursor (TNF-alpha) (Tumor necrosis factorligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumornecrosis factor, membrane form; Tumor necrosis factor, soluble form].|
Synonyms: TNFA, TNFSF2
Ensembl ID: ENSG00000204490
UniprotKB/SwissProt: TNFA_HUMAN (P01375)
Function: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted.