Regulatory Network in Protein Phosphorylation
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Substrate: XRCC1

Description: DNA-repair protein XRCC1 (X-ray repair cross-complementing protein 1).

Ensembl ID: ENSG00000073050

UniprotKB/SwissProt: XRCC1_HUMAN (P18887)

Function: Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Note=Accumulates at sites of DNA damage.
PDB:1CDZ
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of XRCC1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1XRCC1XRCC1_HUMANS266PPAQL S PSVPK 11.75% Swiss-Prot 55.0 View   
2XRCC1XRCC1_HUMANS268AQLSP S VPKRP 47.91% Phospho.ELM 7.0View   
3XRCC1XRCC1_HUMANS371NTPKY S QVLGL 21.68%DNAPK Swiss-Prot 55.0   ViewAnalyzing
4XRCC1XRCC1_HUMANS408MAGPG S SSEED 33.55% Phospho.ELM 7.0View   
5XRCC1XRCC1_HUMANS408MAGPG S SSEED 33.55% Swiss-Prot 55.0 View   
6XRCC1XRCC1_HUMANS409AGPGS S SEEDE 47.92% Swiss-Prot 55.0 View   
7XRCC1XRCC1_HUMANS409AGPGS S SEEDE 47.92% Phospho.ELM 7.0View   
8XRCC1XRCC1_HUMANS410GPGSS S EEDEA 46.86% Swiss-Prot 55.0 View   
9XRCC1XRCC1_HUMANS410GPGSS S EEDEA 46.86% Phospho.ELM 7.0View   
10XRCC1XRCC1_HUMANS416EEDEA S HSGGS 19.01% Swiss-Prot 55.0 View   
11XRCC1XRCC1_HUMANS416EEDEA S HSGGS 19.01% Phospho.ELM 7.0View   
12XRCC1XRCC1_HUMANS418DEASH S GGSGD 42.21% Phospho.ELM 7.0View   
13XRCC1XRCC1_HUMANS418DEASH S GGSGD 42.21% Swiss-Prot 55.0 View   
14XRCC1XRCC1_HUMANS421SHSGG S GDEAP 46.74% Swiss-Prot 55.0 View   
15XRCC1XRCC1_HUMANS421SHSGG S GDEAP 46.74% Phospho.ELM 7.0View   
16XRCC1XRCC1_HUMANS447AAGPS S PQKPP 34.19% Swiss-Prot 55.0 View   
17XRCC1XRCC1_HUMANT453PQKPP T PEETK 52.43% Swiss-Prot 55.0 View   
18XRCC1XRCC1_HUMANT453PQKPP T PEETK 52.43% Phospho.ELM 7.0View   
19XRCC1XRCC1_HUMANS461ETKAA S PVLQE 22.02%CK2a1-rs HPRD:01909(in vitro)  ViewAnalyzing
20XRCC1XRCC1_HUMANS461ETKAA S PVLQE 22.02%CK2a1 HPRD:01909(in vitro)  ViewAnalyzing
21XRCC1XRCC1_HUMANS475IEGVQ S EGQDN 41.09%CK2a1 HPRD:01909(in vitro)  ViewAnalyzing
22XRCC1XRCC1_HUMANS475IEGVQ S EGQDN 41.09%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
23XRCC1XRCC1_HUMANS475IEGVQ S EGQDN 41.09%CK2a1-rs HPRD:01909(in vitro)  ViewAnalyzing
24XRCC1XRCC1_HUMANS485NGAED S GDTED 30.03%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
25XRCC1XRCC1_HUMANS485NGAED S GDTED 30.03%CK2a1-rs HPRD:01909(in vitro)  ViewAnalyzing
26XRCC1XRCC1_HUMANS485NGAED S GDTED 30.03%CK2a1 HPRD:01909(in vitro)  ViewAnalyzing
27XRCC1XRCC1_HUMANT488EDSGD T EDELR 49.19%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
28XRCC1XRCC1_HUMANS518DPYAG S TDENT 25.23%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
29XRCC1XRCC1_HUMANS518DPYAG S TDENT 25.23%CK2a2 HPRD:01909(in vitro;in vivo)  ViewAnalyzing
30XRCC1XRCC1_HUMANT519PYAGS T DENTD 46.55%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
31XRCC1XRCC1_HUMANT519PYAGS T DENTD 46.55%CK2a2 HPRD:01909(in vitro;in vivo)  ViewAnalyzing
32XRCC1XRCC1_HUMANT519PYAGS T DENTD 46.55%CK2a1-rs HPRD:01909(in vitro)  ViewAnalyzing
33XRCC1XRCC1_HUMANT519PYAGS T DENTD 46.55%CK2a1 HPRD:01909(in vitro)  ViewAnalyzing
34XRCC1XRCC1_HUMANT523STDEN T DSEEH 38.56%CK2a2 HPRD:01909(in vitro;in vivo)  ViewAnalyzing
35XRCC1XRCC1_HUMANT523STDEN T DSEEH 38.56%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
36XRCC1XRCC1_HUMANS525DENTD S EEHQE 42.73%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing