Regulatory Network in Protein Phosphorylation
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Substrate: ACACA

Description: Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotincarboxylase (EC 6.3.4.14)].

Synonyms: ACAC, ACC1, ACCA

UniprotKB/SwissProt: ACACA_HUMAN (Q13085)

Function: Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of ACACA

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1ACACAACACA_HUMANS23RFIIG S VSEDN 16.44% Swiss-Prot 55.0 View   
2ACACAACACA_HUMANS23RFIIG S VSEDN 16.44% HPRD:01938(in vitro)View   
3ACACAACACA_HUMANS23RFIIG S VSEDN 16.44% Phospho.ELM 7.0View   
4ACACAACACA_HUMANS25IIGSV S EDNSE 40.71% HPRD:01938(in vitro)View   
5ACACAACACA_HUMANS25IIGSV S EDNSE 40.71% Swiss-Prot 55.0 View   
6ACACAACACA_HUMANS25IIGSV S EDNSE 40.71%CaMK1_group Phospho.ELM 7.0 ViewAnalyzing
7ACACAACACA_HUMANS29VSEDN S EDEIS 59.76%CK2a2 HPRD:01938(in vitro)  ViewAnalyzing
8ACACAACACA_HUMANS29VSEDN S EDEIS 59.76%CK2_group Phospho.ELM 7.0 ViewAnalyzing
9ACACAACACA_HUMANS29VSEDN S EDEIS 59.76% HPRD:01938(in vitro)View   
10ACACAACACA_HUMANS29VSEDN S EDEIS 59.76% HPRD:01938(in vivo)View   
11ACACAACACA_HUMANS29VSEDN S EDEIS 59.76% Swiss-Prot 55.0 View   
12ACACAACACA_HUMANS29VSEDN S EDEIS 59.76%CK2a1 HPRD:01938(in vitro)  ViewAnalyzing
13ACACAACACA_HUMAN