|Description: DNA-(apurinic or apyrimidinic site) lyase (EC 188.8.131.52) (APendonuclease 1) (APEX nuclease) (APEN) (Protein REF-1).|
Synonyms: APE, APEX, APX, HAP1, REF1
Ensembl ID: ENSG00000100823
UniprotKB/SwissProt: APEX1_HUMAN (P27695)
Function: Repairs oxidative DNA damages in vitro. May have a role in protection against cell lethality and suppression of mutations. Removes the blocking groups from the 3'-termini of the DNA strand breaks generated by ionizing radiations and bleomycin.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus.