Regulatory Network in Protein Phosphorylation
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Substrate: APEX1

Description: DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (APendonuclease 1) (APEX nuclease) (APEN) (Protein REF-1).

Synonyms: APE, APEX, APX, HAP1, REF1

Ensembl ID: ENSG00000100823

UniprotKB/SwissProt: APEX1_HUMAN (P27695)

Function: Repairs oxidative DNA damages in vitro. May have a role in protection against cell lethality and suppression of mutations. Removes the blocking groups from the 3'-termini of the DNA strand breaks generated by ionizing radiations and bleomycin.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
PDB:1BIX
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of APEX1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1APEX1APEX1_HUMANS123YWSAP S DKEGY 62.12%CK2a1 HPRD:00136(in vitro)  ViewAnalyzing
2APEX1APEX1_HUMANS123YWSAP S DKEGY 62.12%CK2a1-rs HPRD:00136(in vitro)  ViewAnalyzing
3APEX1APEX1_HUMANY262YPNTP Y AYTFW 15.36% Swiss-Prot 55.0 View   
4APEX1APEX1_HUMANS290FLLSH S LLPAL 28.38%CK2_group Phospho.ELM 7.0 ViewAnalyzing