Regulatory Network in Protein Phosphorylation
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Substrate: BCR

Description: Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinomaantigen NY-REN-26).

Synonyms: BCR1, D22S11

Ensembl ID: ENSG00000186716

UniprotKB/SwissProt: BCR_HUMAN (P11274)

Function: GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
PDB:1K1F
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of BCR

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1BCRBCR_HUMANY177AEKPF Y VNVEF 10.31% Swiss-Prot 55.0 View   
2BCRBCR_HUMANY177AEKPF Y VNVEF 10.31%HCK HPRD:01044(in vivo)  ViewAnalyzing
3BCRBCR_HUMANY177AEKPF Y VNVEF 10.31%HCK Phospho.ELM 7.0  ViewAnalyzing
4BCRBCR_HUMANY177AEKPF Y VNVEF 10.31%FES HPRD:01044(in vitro;in vivo)  ViewAnalyzing
5BCRBCR_HUMANY177AEKPF Y VNVEF 10.31%ABL1 Phospho.ELM 7.0  ViewAnalyzing
6BCRBCR_HUMANY177AEKPF Y VNVEF 10.31%Fes Phospho.ELM 7.0  ViewAnalyzing
7BCRBCR_HUMANY231ASRPP Y RGRSS 28.51% Phospho.ELM 7.0View   
8BCRBCR_HUMANS236YRGRS S ESSCG 39.89% Swiss-Prot 55.0 (Similarity)View   
9BCRBCR_HUMANY246GVDGD Y EDAEL 22.65%FES HPRD:01044(in vitro;in vivo)  ViewAnalyzing
10BCRBCR_HUMANY246GVDGD Y EDAEL 22.65%Fes Phospho.ELM 7.0  ViewAnalyzing
11BCRBCR_HUMANY246GVDGD Y EDAEL 22.65% Swiss-Prot 55.0 (Similarity)View   
12BCRBCR_HUMANY276WPPLE Y QPYQS 23.59%FES HPRD:01044(in vitro)  ViewAnalyzing
13BCRBCR_HUMANY276WPPLE Y QPYQS 23.59%Fes Phospho.ELM 7.0  ViewAnalyzing
14BCRBCR_HUMANY279LEYQP Y QSIYV 10.20%FES HPRD:01044(in vitro)  ViewAnalyzing
15BCRBCR_HUMANY279LEYQP Y QSIYV 10.20%Fes Phospho.ELM 7.0  ViewAnalyzing
16BCRBCR_HUMANY283PYQSI Y VGGMM 9.78%Fes Phospho.ELM 7.0  ViewAnalyzing
17BCRBCR_HUMANY283PYQSI Y VGGMM 9.78% HPRD:01044(in vitro)View   
18BCRBCR_HUMANT310QEKRL T WPRRS 37.14% Phospho.ELM 7.0View   
19BCRBCR_HUMANT310QEKRL T WPRRS 37.14% Swiss-Prot 55.0 View   
20BCRBCR_HUMANT310QEKRL T WPRRS 37.14% HPRD:01044(in vivo)View   
21BCRBCR_HUMANY328DCGGG Y TPDCS 20.55% HPRD:01044(in vitro)View   
22BCRBCR_HUMANY328DCGGG Y TPDCS 20.55% Phospho.ELM 7.0View   
23BCRBCR_HUMANS354QSSRV S PSPTT 20.67% HPRD:01044(in vitro;in vivo)View   
24BCRBCR_HUMANY360PSPTT Y RMFRD 11.54% HPRD:01044(in vitro)View   
25BCRBCR_HUMANY360PSPTT Y RMFRD 11.54%ABL1 Phospho.ELM 7.0  ViewAnalyzing
26BCRBCR_HUMANY436GTPPG Y GCAAD 18.14% Phospho.ELM 7.0View   
27BCRBCR_HUMANS459PYIDD S PSSSP 23.96% Phospho.ELM 7.0View   
28BCRBCR_HUMANS459PYIDD S PSSSP 23.96% HPRD:01044(in vivo)View   
29BCRBCR_HUMANS459PYIDD S PSSSP 23.96% Swiss-Prot 55.0 View   
30BCRBCR_HUMANS463DSPSS S PHLSS 22.22% Phospho.ELM 7.0View   
31BCRBCR_HUMANS463DSPSS S PHLSS 22.22% HPRD:01044(in vivo)View   
32BCRBCR_HUMANS463DSPSS S PHLSS 22.22% Swiss-Prot 55.0 View   
33BCRBCR_HUMANY591SQLGV Y RAFVD 8.40% Swiss-Prot 55.0 View   
34BCRBCR_HUMANY591SQLGV Y RAFVD 8.40% HPRD:01044(in vivo)View   
35BCRBCR_HUMANY591SQLGV Y RAFVD 8.40% Phospho.ELM 7.0View   
36BCRBCR_HUMANY598AFVDN Y GVAME 14.44% Phospho.ELM 7.0View   
37BCRBCR_HUMANY644LETLL Y KPVDR 19.16% HPRD:01044(in vivo)View   
38BCRBCR_HUMANY644LETLL Y KPVDR 19.16% Swiss-Prot 55.0 View   
39BCRBCR_HUMANY644LETLL Y KPVDR 19.16% Phospho.ELM 7.0View   
40BCRBCR_HUMANS1264DSKRQ S ILFST 25.87% Swiss-Prot 55.0 View   
41BCRBCR_HUMANS1264DSKRQ S ILFST 25.87%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing