Regulatory Network in Protein Phosphorylation
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Substrate: BID

Description: BH3-interacting domain death agonist (BID) (p22 BID) [Contains: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domaindeath agonist p13 (p13 BID); BH3-interacting domain death agonist p11(p11 BID)].

Ensembl ID: ENSG00000015475

UniprotKB/SwissProt: BID_HUMAN (P55957)

Function: The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Mitochondrion membrane (By similarity). Note=When uncleaved, it is predominantly cytoplasmic. BH3-interacting domain death agonist p15: Mitochondrion membrane (By similarity). Note=Translocates to mitochondria as an integral me
PDB:1ZY3
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of BID

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1BIDBID_HUMANY54PQWEG Y DELQT 8.50% Phospho.ELM 7.0View   
2BIDBID_HUMANY54PQWEG Y DELQT 8.50% Swiss-Prot 55.0 View   
3BIDBID_HUMANT59YDELQ T DGNRS 59.50%CK2_group Phospho.ELM 7.0 ViewAnalyzing
4BIDBID_HUMANT59YDELQ T DGNRS 59.50%CK1_group Phospho.ELM 7.0 ViewAnalyzing
5BIDBID_HUMANT59YDELQ T DGNRS 59.50%CK2a1 HPRD:03590(in vitro;in vivo)  ViewAnalyzing
6BIDBID_HUMANT59YDELQ T DGNRS 59.50%CK1a HPRD:03590(in vitro;in vivo)  ViewAnalyzing
7BIDBID_HUMANT59YDELQ T DGNRS 59.50%CK1e HPRD:03590(in vitro;in vivo)  ViewAnalyzing
8BIDBID_HUMANT59YDELQ T DGNRS 59.50%P67870(Casein kinase II, beta) HPRD:03590(in vitro;in vivo) ViewAnalyzing
9BIDBID_HUMANT59YDELQ T DGNRS 59.50%CK2a1-rs HPRD:03590(in vitro;in vivo)  ViewAnalyzing
10BIDBID_HUMANT59YDELQ T DGNRS 59.50%CK2a2 HPRD:03590(in vitro;in vivo)  ViewAnalyzing
11BIDBID_HUMANS64TDGNR S SHSRL 36.08%CK2a1-rs HPRD:03590(in vitro;in vivo)  ViewAnalyzing
12BIDBID_HUMANS64TDGNR S SHSRL 36.08%P67870(Casein kinase II, beta) HPRD:03590(in vivo) ViewAnalyzing
13BIDBID_HUMANS64TDGNR S SHSRL 36.08%CK1e HPRD:03590(in vitro;in vivo)  ViewAnalyzing
14BIDBID_HUMANS64TDGNR S SHSRL 36.08%CK1a HPRD:03590(in vitro;in vivo)  ViewAnalyzing
15BIDBID_HUMANS64TDGNR S SHSRL 36.08%CK2a1 HPRD:03590(in vitro;in vivo)  ViewAnalyzing
16BIDBID_HUMANS64TDGNR S SHSRL 36.08%CK1_group Phospho.ELM 7.0 ViewAnalyzing
17BIDBID_HUMANS64TDGNR S SHSRL 36.08%CK2_group Phospho.ELM 7.0 ViewAnalyzing
18BIDBID_HUMANS64TDGNR S SHSRL 36.08%CK2a2 HPRD:03590(in vitro;in vivo)  ViewAnalyzing
19BIDBID_HUMANS78EADSE S QEDII 42.70% Phospho.ELM 7.0View   
20BIDBID_HUMANS78EADSE S QEDII 42.70% Swiss-Prot 55.0 View