Regulatory Network in Protein Phosphorylation
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Substrate: CAV1

Description: Caveolin-1.

Synonyms: CAV

Ensembl ID: ENSG00000105974

UniprotKB/SwissProt: CAV1_HUMAN (Q03135)

Function: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane, caveola; Peripheral membrane protein; Cytoplasmic side. Note=Membrane protein of caveolae. Potential hairpin-like structure in the membrane.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CAV1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CAV1CAV1_HUMANY6MSGGK Y VDSEG 16.86% Swiss-Prot 55.0 View   
2CAV1CAV1_HUMANY6MSGGK Y VDSEG 16.86% HPRD:03028(in vivo)View   
3CAV1CAV1_HUMANY6MSGGK Y VDSEG 16.86% Phospho.ELM 7.0View   
4CAV1CAV1_HUMANY14SEGHL Y TVPIR 10.46%Fyn Phospho.ELM 7.0  ViewAnalyzing
5CAV1CAV1_HUMANY14SEGHL Y TVPIR 10.46% Swiss-Prot 55.0 View   
6CAV1CAV1_HUMANY14SEGHL Y TVPIR 10.46%Src Phospho.ELM 7.0  ViewAnalyzing
7CAV1CAV1_HUMANY14SEGHL Y TVPIR 10.46%SRC HPRD:03028(in vivo)  ViewAnalyzing
8CAV1CAV1_HUMANY25EQGNI Y KPNNK 25.13% Swiss-Prot 55.0 View   
9CAV1CAV1_HUMANY25EQGNI Y KPNNK 25.13% Phospho.ELM 7.0View   
10CAV1CAV1_HUMANS37MADEL S EKQVY 40.47% Swiss-Prot 55.0 View   
11CAV1CAV1_HUMANS37MADEL S EKQVY 40.47% Phospho.ELM 7.0View   
12CAV1CAV1_HUMANS80PEGTH S FDGIW 25.52% HPRD:03028(in vitro)View   
13CAV1CAV1_HUMANS80PEGTH S FDGIW 25.52% Phospho.ELM 7.0View   
14CAV1CAV1_HUMANS88GIWKA S FTTFT 21.28%CK2a1-rs HPRD:03028(in vitro)  ViewAnalyzing
15CAV1CAV1_HUMANS88GIWKA S FTTFT 21.28%CK2_group Phospho.ELM 7.0 ViewAnalyzing
16CAV1CAV1_HUMANS88GIWKA S FTTFT 21.28%CK2a2 HPRD:03028(in vitro)  ViewAnalyzing
17CAV1CAV1_HUMANS88GIWKA S FTTFT 21.28%CK2a1 HPRD:03028(in vitro)  ViewAnalyzing
18CAV1CAV1_HUMANS168VGKIF S NVRIN 37.58% HPRD:03028(in vitro)View   
19CAV1CAV1_HUMANS168VGKIF S NVRIN 37.58% Phospho.ELM 7.0View