|Description: Cyclin-H (MO15-associated protein) (p37) (p34).|
Ensembl ID: ENSG00000134480
UniprotKB/SwissProt: CCNH_HUMAN (P51946)
Function: Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus.