Regulatory Network in Protein Phosphorylation
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Substrate: CDKN1B

Description: Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinaseinhibitor p27) (p27Kip1).

Synonyms: KIP1

Ensembl ID: ENSG00000111276

UniprotKB/SwissProt: CDN1B_HUMAN (P46527)

Function: Involved in G1 arrest. May mediate TGF beta-induced G1 arrest. Binds to and inhibits complexes formed by cyclin E-CDK2, cyclin A-CDK2, and cyclin D1-CDK4. Interaction with nucleoporin NUP50 is required for nuclear import and for degradation of phosphorylated p27Kip1 after nuclear import (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus (By similarity). Cytoplasm (By similarity). Note=Nuclear and cytoplasmic in quiescent cells. Upon cell cycle progression, mostly cytoplasmic (By similarity).
PDB:1H27
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CDKN1B

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CDKN1BCDN1B_HUMANS10RVSNG S PSLER 18.63%KIS Swiss-Prot 55.0   ViewAnalyzing
2CDKN1BCDN1B_HUMANS10RVSNG S PSLER 18.63%CDK2 Phospho.ELM 7.0  ViewAnalyzing
3CDKN1BCDN1B_HUMANS10RVSNG S PSLER 18.63% HPRD:02867(in vivo)View   
4CDKN1BCDN1B_HUMANS10RVSNG S PSLER 18.63%KIS Phospho.ELM 7.0  ViewAnalyzing
5CDKN1BCDN1B_HUMANS83EVEKG S LPEFY 52.39%CK2a1(CK2 alpha) Phospho.ELM 7.0 ViewAnalyzing
6CDKN1BCDN1B_HUMANY88SLPEF Y YRPPR 9.26%ABL1 HPRD:02867(in vitro;in vivo)  ViewAnalyzing
7CDKN1BCDN1B_HUMANY88SLPEF Y YRPPR 9.26%LYN HPRD:02867(in vitro;in vivo)  ViewAnalyzing
8CDKN1BCDN1B_HUMANY88SLPEF Y YRPPR 9.26% Phospho.ELM 7.0View   
9CDKN1BCDN1B_HUMANY89LPEFY Y RPPRP 23.20% Phospho.ELM 7.0View   
10CDKN1BCDN1B_HUMANS140TDPSD S QTGLA 33.70% Swiss-Prot 55.0 View   
11CDKN1BCDN1B_HUMANT157RKRPA T DDSST 42.92%AKT_group Phospho.ELM 7.0 ViewAnalyzing
12CDKN1BCDN1B_HUMANT157RKRPA T DDSST 42.92%AKT1 HPRD:02867(in vitro;in vivo)  ViewAnalyzing
13CDKN1BCDN1B_HUMANS178NVSDG S PNAGS 21.70%Erk2(MAPK1) Phospho.ELM 7.0 ViewAnalyzing
14CDKN1BCDN1B_HUMANT187GSVEQ T PKKPG 24.46%Erk2(MAPK1) Phospho.ELM 7.0 ViewAnalyzing
15CDKN1BCDN1B_HUMANT187GSVEQ T PKKPG 24.46%CDK2 HPRD:02867(in vitro)  ViewAnalyzing
16CDKN1BCDN1B_HUMANT187GSVEQ T PKKPG 24.46%CDK2 Phospho.ELM 7.0  ViewAnalyzing
17CDKN1BCDN1B_HUMANT198LRRRQ T  38.47%RSK_group Phospho.ELM 7.0 ViewAnalyzing
18CDKN1BCDN1B_HUMANT198LRRRQ T  38.47%AKT_group Phospho.ELM 7.0 ViewAnalyzing
19CDKN1BCDN1B_HUMANT198LRRRQ T  38.47%RSK2 Phospho.ELM 7.0  ViewAnalyzing