Regulatory Network in Protein Phosphorylation
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Substrate: CREM

Description: cAMP-responsive element modulator (Inducible cAMP early repressor)(ICER).

Ensembl ID: ENSG00000095794

UniprotKB/SwissProt: CREM_HUMAN (Q03060)

Function: Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CREM

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CREMCREM_HUMANS42ALAQV S VAGSG 8.31% HPRD:00444(in vitro;in vivo)View   
2CREMCREM_HUMANS83WVIQS S EIHTV 24.97%GSK3A HPRD:00444(in vitro;in vivo)  ViewAnalyzing
3CREMCREM_HUMANS83WVIQS S EIHTV 24.97% HPRD:00444(in vitro;in vivo)View   
4CREMCREM_HUMANS83WVIQS S EIHTV 24.97%GSK3B HPRD:00444(in vitro;in vivo)  ViewAnalyzing
5CREMCREM_HUMANT96AAIAE T DESAE 35.72% HPRD:00444(in vitro;in vivo)View   
6CREMCREM_HUMANT96AAIAE T DESAE 35.72%CK2a1 HPRD:00444(in vitro;in vivo)  ViewAnalyzing
7CREMCREM_HUMANT96AAIAE T DESAE 35.72%CK2a2 HPRD:00444(in vitro;in vivo)  ViewAnalyzing
8CREMCREM_HUMANT96AAIAE T DESAE 35.72%CK2a1-rs HPRD:00444(in vitro;in vivo)  ViewAnalyzing
9CREMCREM_HUMANS99AETDE S AESEG 39.90%CK1a HPRD:00444(in vitro;in vivo)  ViewAnalyzing
10CREMCREM_HUMANS108EGVID S HKRRE 21.56% HPRD:00444(in vitro;in vivo)View   
11CREMCREM_HUMANS116RREIL S RRPSY 31.72% Phospho.ELM 7.0View   
12CREMCREM_HUMANS116RREIL S RRPSY 31.72% HPRD:00444(in vitro;in vivo)View   
13CREMCREM_HUMANS120LSRRP S YRKIL 35.44%CaMK2g HPRD:00444(in vitro;in vivo)  ViewAnalyzing
14CREMCREM_HUMANS120LSRRP S YRKIL 35.44%CaMK2d HPRD:00444(in vitro;in vivo)  ViewAnalyzing
15CREMCREM_HUMANS120LSRRP S YRKIL 35.44%PKACa HPRD:00444(in vitro;in vivo)  ViewAnalyzing
16CREMCREM_HUMANS120LSRRP S YRKIL 35.44% HPRD:00444(in vitro;in vivo)View   
17CREMCREM_HUMANS120LSRRP S YRKIL 35.44%CDC2 HPRD:00444(in vitro;in vivo)  ViewAnalyzing
18CREMCREM_HUMANS120LSRRP S YRKIL 35.44%PKCa HPRD:00444(in vitro;in vivo)  ViewAnalyzing
19CREMCREM_HUMANS129ILNEL S SDVPG 20.50% HPRD:00444(in vitro;in vivo)View   
20CREMCREM_HUMANS130LNELS S DVPGV 56.08% HPRD:00444(in vitro;in vivo)View   
21CREMCREM_HUMANS143IEEER S EEEGT 53.27%CK2a2 HPRD:00444(in vitro;in vivo)  ViewAnalyzing
22CREMCREM_HUMANS143IEEER S EEEGT 53.27%CK1a HPRD:00444(in vitro;in vivo)  ViewAnalyzing
23CREMCREM_HUMANS143IEEER S EEEGT 53.27%CK2a1-rs HPRD:00444(in vitro;in vivo)  ViewAnalyzing
24CREMCREM_HUMANS143IEEER S EEEGT 53.27%CDC2 HPRD:00444(in vitro;in vivo)  ViewAnalyzing
25CREMCREM_HUMANS143IEEER S EEEGT 53.27%CK2a1 HPRD:00444(in vitro;in vivo)  ViewAnalyzing
26CREMCREM_HUMANS143IEEER S EEEGT 53.27% HPRD:00444(in vitro;in vivo)View