Regulatory Network in Protein Phosphorylation
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Substrate: CTDP1

Description: RNA polymerase II subunit A C-terminal domain phosphatase(EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

Synonyms: FCP1

Ensembl ID: ENSG00000060069

UniprotKB/SwissProt: CTDP1_HUMAN (Q9Y5B0)

Function: Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
PDB:1J2X
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CTDP1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CTDP1CTDP1_HUMANS575ESLDQ S MEEEE 28.03%P67870(Casein kinase II, beta) HPRD:05377(in vitro;in vivo) ViewAnalyzing
2CTDP1CTDP1_HUMANS575ESLDQ S MEEEE 28.03%CK2a1-rs HPRD:05377(in vitro;in vivo)  ViewAnalyzing
3CTDP1CTDP1_HUMANS575ESLDQ S MEEEE 28.03%CK2a1 HPRD:05377(in vitro;in vivo)  ViewAnalyzing
4CTDP1CTDP1_HUMANS575ESLDQ S MEEEE 28.03%CK2_group Phospho.ELM 7.0 ViewAnalyzing
5CTDP1CTDP1_HUMANS575ESLDQ S MEEEE 28.03%CK2a2 HPRD:05377(in vitro;in vivo)  ViewAnalyzing
6CTDP1CTDP1_HUMANS674TRLVL S PDAPD 17.16% Swiss-Prot 55.0 View   
7CTDP1CTDP1_HUMANS740AQREN S PAAFP 15.91%CK2_group Phospho.ELM 7.0 ViewAnalyzing
8CTDP1CTDP1_HUMANS740AQREN S PAAFP 15.91% Swiss-Prot 55.0 View   
9CTDP1CTDP1_HUMANS740AQREN S PAAFP 15.91%CK2a1 HPRD:05377(in vitro;in vivo)  ViewAnalyzing
10CTDP1CTDP1_HUMANS740AQREN S PAAFP 15.91%CK2a1-rs HPRD:05377(in vitro;in vivo)  ViewAnalyzing
11CTDP1CTDP1_HUMANS740AQREN S PAAFP 15.91%CK2a2 HPRD:05377(in vitro;in vivo)  ViewAnalyzing
12CTDP1CTDP1_HUMANS740AQREN S PAAFP 15.91%P67870(Casein kinase II, beta) HPRD:05377(in vitro;in vivo) ViewAnalyzing
13CTDP1CTDP1_HUMANS869ILGEG S DDSDS 33.66% Swiss-Prot 55.0 View   
14CTDP1CTDP1_HUMANS869ILGEG S DDSDS 33.66% Phospho.ELM 7.0View   
15CTDP1CTDP1_HUMANS872EGSDD S DSEKR 48.29% Phospho.ELM 7.0View   
16CTDP1CTDP1_HUMANS872EGSDD S DSEKR 48.29% Swiss-Prot 55.0 View