Regulatory Network in Protein Phosphorylation
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Substrate: CTNNB1

Description: Catenin beta-1 (Beta-catenin).

Synonyms: CTNNB

Ensembl ID: ENSG00000168036

UniprotKB/SwissProt: CTNB1_HUMAN (P35222)

Function: Involved in the regulation of cell adhesion and in signal transduction through the Wnt pathway.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 and MUC1 promotes nuclear translocatio
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CTNNB1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CTNNB1CTNB1_HUMANS23RKAAV S HWQQQ 17.80%GSK3B(GSK3 beta) Swiss-Prot 55.0  ViewAnalyzing
2CTNNB1CTNB1_HUMANS29HWQQQ S YLDSG 24.27%GSK3B(GSK3 beta) Swiss-Prot 55.0  ViewAnalyzing
3CTNNB1CTNB1_HUMANS29HWQQQ S YLDSG 24.27%P67870(Casein kinase II, beta) HPRD:00286(in vitro;in vivo) ViewAnalyzing
4CTNNB1CTNB1_HUMANS29HWQQQ S YLDSG 24.27%CK2a1-rs HPRD:00286(in vitro;in vivo)  ViewAnalyzing
5CTNNB1CTNB1_HUMANS29HWQQQ S YLDSG 24.27%CK2a1 HPRD:00286(in vitro;in vivo)  ViewAnalyzing
6CTNNB1CTNB1_HUMANS33QSYLD S GIHSG 36.73%GSK_group Phospho.ELM 7.0 ViewAnalyzing
7CTNNB1CTNB1_HUMANS33QSYLD S GIHSG 36.73%GSK3B(GSK3 beta) Swiss-Prot 55.0  ViewAnalyzing
8CTNNB1CTNB1_HUMANS33QSYLD S GIHSG 36.73%GSK3B HPRD:00286(in vitro;in vivo)  ViewAnalyzing
9CTNNB1CTNB1_HUMANS37DSGIH S GATTT 28.36%GSK3B HPRD:00286(in vitro;in vivo)  ViewAnalyzing
10CTNNB1CTNB1_HUMANS37DSGIH S GATTT 28.36%GSK_group Phospho.ELM 7.0 ViewAnalyzing
11CTNNB1CTNB1_HUMANS37DSGIH S GATTT 28.36%GSK3B(GSK3 beta) Swiss-Prot 55.0  ViewAnalyzing
12CTNNB1CTNB1_HUMANT41HSGAT T TAPSL 22.04%GSK3B(GSK3 beta) Swiss-Prot 55.0  ViewAnalyzing
13CTNNB1CTNB1_HUMANT41HSGAT T TAPSL 22.04%GSK_group Phospho.ELM 7.0 ViewAnalyzing
14CTNNB1CTNB1_HUMANT41HSGAT T TAPSL 22.04%GSK3B HPRD:00286(in vitro;in vivo)  ViewAnalyzing
15CTNNB1CTNB1_HUMANS45TTTAP S LSGKG 32.48%CK1d HPRD:00286(in vitro)  ViewAnalyzing
16CTNNB1CTNB1_HUMANS45TTTAP S LSGKG 32.48%CK1a HPRD:00286(in vitro;in vivo)  ViewAnalyzing
17CTNNB1CTNB1_HUMANS45TTTAP S LSGKG 32.48%CK1_group Phospho.ELM 7.0 ViewAnalyzing
18CTNNB1CTNB1_HUMANS45TTTAP S LSGKG 32.48%CDK6 HPRD:00286(in vitro;in vivo)  ViewAnalyzing
19CTNNB1CTNB1_HUMANS45TTTAP S LSGKG 32.48% Swiss-Prot 55.0 View   
20CTNNB1CTNB1_HUMANY86DIDGQ Y AMTRA 12.13%SRC HPRD:00286(in vitro)  ViewAnalyzing
21CTNNB1CTNB1_HUMANY86DIDGQ Y AMTRA 12.13%CSK Swiss-Prot 55.0   ViewAnalyzing
22CTNNB1CTNB1_HUMANY86DIDGQ Y AMTRA 12.13%Src Phospho.ELM 7.0  ViewAnalyzing
23CTNNB1CTNB1_HUMANT102AMFPE T LDEGM 39.48%CK2_group Phospho.ELM 7.0 ViewAnalyzing
24CTNNB1CTNB1_HUMANT102AMFPE T LDEGM 39.48%CK2a1 HPRD:00286(in vitro;in vivo)  ViewAnalyzing
25CTNNB1CTNB1_HUMANT102AMFPE T LDEGM 39.48%CK2a1-rs HPRD:00286(in vitro;in vivo)  ViewAnalyzing
26CTNNB1CTNB1_HUMANT102AMFPE T LDEGM 39.48%P67870(Casein kinase II, beta) HPRD:00286(in vitro;in vivo) ViewAnalyzing
27CTNNB1CTNB1_HUMANT112MQIPS T QFDAA 28.09%CK2a1-rs HPRD:00286(in vitro;in vivo)  ViewAnalyzing
28CTNNB1CTNB1_HUMANT112MQIPS T QFDAA 28.09%P67870(Casein kinase II, beta) HPRD:00286(in vitro;in vivo) ViewAnalyzing
29CTNNB1CTNB1_HUMANT112MQIPS T QFDAA 28.09%CK2_group Phospho.ELM 7.0 ViewAnalyzing
30CTNNB1CTNB1_HUMANT112MQIPS T QFDAA 28.09%CK2a1 HPRD:00286(in vitro;in vivo)  ViewAnalyzing
31CTNNB1CTNB1_HUMANY142VNLIN Y QDDAE 13.31%FER HPRD:00286(in vitro)  ViewAnalyzing
32CTNNB1CTNB1_HUMANY142VNLIN Y QDDAE 13.31%FYN HPRD:00286(in vitro)  ViewAnalyzing
33CTNNB1CTNB1_HUMANY142VNLIN Y QDDAE 13.31%Fyn Phospho.ELM 7.0  ViewAnalyzing
34CTNNB1CTNB1_HUMANS191HAIMR S PQMVS 11.34% Swiss-Prot 55.0 (Similarity)View   
35CTNNB1CTNB1_HUMANT393LSDAA T KQEGM 34.67%CK2_group Phospho.ELM 7.0 ViewAnalyzing
36CTNNB1CTNB1_HUMANT393LSDAA T KQEGM 34.67%CK2a1 HPRD:00286(in vitro)  ViewAnalyzing
37CTNNB1CTNB1_HUMANT393LSDAA T KQEGM 34.67%CK2a1-rs HPRD:00286(in vitro)  ViewAnalyzing
38CTNNB1CTNB1_HUMANT551DTQRR T SMGGT 25.84% Swiss-Prot 55.0 (Similarity)View   
39CTNNB1CTNB1_HUMANS552TQRRT S MGGTQ 17.39% Swiss-Prot 55.0 View   
40CTNNB1CTNB1_HUMANT556TSMGG T QQQFV 19.92% Swiss-Prot 55.0 (Similarity)View   
41CTNNB1CTNB1_HUMANY654EGVAT Y AAAVL 5.63%SRC HPRD:00286(in vitro)  ViewAnalyzing
42CTNNB1CTNB1_HUMANY654EGVAT Y AAAVL 5.63%Src Phospho.ELM 7.0  ViewAnalyzing
43CTNNB1CTNB1_HUMANY654EGVAT Y AAAVL 5.63%CSK Swiss-Prot 55.0   ViewAnalyzing
44CTNNB1CTNB1_HUMANS675YKKRL S VELTS 19.99% Swiss-Prot 55.0 View   
45CTNNB1CTNB1_HUMANS675YKKRL S VELTS 19.99% HPRD:00286(in vitro)View   
46CTNNB1CTNB1_HUMANS675YKKRL S VELTS 19.99% Phospho.ELM 7.0View