Regulatory Network in Protein Phosphorylation
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Substrate: CTNNB1

Description: Catenin beta-1 (Beta-catenin).

Synonyms: CTNNB

Ensembl ID: ENSG00000168036

UniprotKB/SwissProt: CTNB1_HUMAN (P35222)

Function: Involved in the regulation of cell adhesion and in signal transduction through the Wnt pathway.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 and MUC1 promotes nuclear translocatio
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CTNNB1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CTNNB1CTNB1_HUMANS23RKAAV S HWQQQ 17.80%GSK3B(GSK3 beta) Swiss-Prot 55.0  ViewAnalyzing
2CTNNB1CTNB1_HUMANS29HWQQQ S YLDSG 24.27%GSK3B(GSK3 beta) Swiss-Prot 55.0  ViewAnalyzing
3CTNNB1CTNB1_HUMANS29HWQQQ S YLDSG 24.27%P67870(Casein kinase II, beta) HPRD:00286(in vitro;in vivo) ViewAnalyzing
4CTNNB1CTNB1_HUMANS29HWQQQ S YLDSG 24.27%CK2a1-rs HPRD:00286(in vitro;in vivo)  ViewAnalyzing
5CTNNB1CTNB1_HUMANS29HWQQQ S YLDSG 24.27%CK2a1 HPRD:00286(in vitro;in vivo)  ViewAnalyzing
6CTNNB1CTNB1_HUMANS33QSYLD S GIHSG 36.73%GSK_group Phospho.ELM 7.0 View