Regulatory Network in Protein Phosphorylation
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Substrate: EIF2B5

Description: Translation initiation factor eIF-2B subunit epsilon (eIF-2B GDP-GTPexchange factor subunit epsilon).

Synonyms: EIF2BE

Ensembl ID: ENSG00000145191

UniprotKB/SwissProt: EI2BE_HUMAN (Q13144)

Function: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of EIF2B5

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1EIF2B5EI2BE_HUMANS51VLVAD S FDRRF 21.22%CK1a HPRD:04898(in vitro;in vivo)  ViewAnalyzing
2EIF2B5EI2BE_HUMANS466DDGEF S DDSGA 35.88% Phospho.ELM 7.0View   
3EIF2B5EI2BE_HUMANS466DDGEF S DDSGA 35.88%CK1a HPRD:04898(in vitro;in vivo)  ViewAnalyzing
4EIF2B5EI2BE_HUMANS469EFSDD S GADQE 40.65%CK1a HPRD:04898(in vitro;in vivo)  ViewAnalyzing
5EIF2B5EI2BE_HUMANS469EFSDD S GADQE 40.65% Phospho.ELM 7.0View   
6EIF2B5EI2BE_HUMANS525NMEEE S ESESE 50.10% Swiss-Prot 55.0 View   
7EIF2B5EI2BE_HUMANS527EEESE S ESEQS 56.56% Swiss-Prot 55.0 View   
8EIF2B5EI2BE_HUMANS529ESESE S EQSMD 50.65% Swiss-Prot 55.0 View   
9EIF2B5EI2BE_HUMANS532SESEQ S MDSEE 22.09% Swiss-Prot 55.0 View   
10EIF2B5EI2BE_HUMANS535EQSMD S EEPDS 34.91%GSK3B HPRD:04898(in vitro;in vivo)  ViewAnalyzing
11EIF2B5EI2BE_HUMANS535EQSMD S EEPDS 34.91% Swiss-Prot 55.0 View   
12EIF2B5EI2BE_HUMANS535EQSMD S EEPDS 34.91%GSK_group Phospho.ELM 7.0 ViewAnalyzing
13EIF2B5EI2BE_HUMANS540SEEPD S RGGSP 43.47%GSK3A HPRD:04898(in vitro;in vivo)  ViewAnalyzing
14EIF2B5EI2BE_HUMANS540SEEPD S RGGSP 43.47% Swiss-Prot 55.0 View   
15EIF2B5EI2BE_HUMANS540SEEPD S RGGSP 43.47%GSK3B HPRD:04898(in vitro;in vivo)  ViewAnalyzing
16EIF2B5EI2BE_HUMANS544DSRGG S PQMDD 18.12%GSK3B HPRD:04898(in vitro;in vivo)  ViewAnalyzing
17EIF2B5EI2BE_HUMANS544DSRGG S PQMDD 18.12%GSK3A HPRD:04898(in vitro;in vivo)  ViewAnalyzing
18EIF2B5EI2BE_HUMANS544DSRGG S PQMDD 18.12% Swiss-Prot 55.0 View   
19EIF2B5EI2BE_HUMANS544DSRGG S PQMDD 18.12% Phospho.ELM 7.0View   
20EIF2B5EI2BE_HUMANS717EAEEE S SEDD 42.16% Phospho.ELM 7.0View   
21EIF2B5EI2BE_HUMANS717EAEEE S SEDD 42.16%CK2a1 HPRD:04898(in vitro;in vivo)  ViewAnalyzing
22EIF2B5EI2BE_HUMANS717EAEEE S SEDD 42.16%CK2a1-rs HPRD:04898(in vitro;in vivo)  ViewAnalyzing
23EIF2B5EI2BE_HUMANS717EAEEE S SEDD 42.16%CK2a2 HPRD:04898(in vitro;in vivo)  ViewAnalyzing
24EIF2B5EI2BE_HUMANS718AEEES S EDD 48.61% Phospho.ELM 7.0View   
25EIF2B5EI2BE_HUMANS718AEEES S EDD 48.61%CK2a2 HPRD:04898(in vitro;in vivo)  ViewAnalyzing
26EIF2B5EI2BE_HUMANS718AEEES S EDD 48.61%CK2a1 HPRD:04898(in vitro;in vivo)  ViewAnalyzing
27EIF2B5EI2BE_HUMANS718AEEES S EDD 48.61%CK2a1-rs HPRD:04898(in vitro;in vivo)  ViewAnalyzing