Regulatory Network in Protein Phosphorylation
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Substrate: EIF2S2

Description: Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotictranslation initiation factor 2 subunit beta) (eIF-2-beta).

Synonyms: EIF2B

Ensembl ID: ENSG00000125977

UniprotKB/SwissProt: IF2B_HUMAN (P20042)

Function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of EIF2S2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1EIF2S2IF2B_HUMANS2----M S GDEMI 55.76% Swiss-Prot 55.0 View   
2EIF2S2IF2B_HUMANS2----M S GDEMI 55.76% Phospho.ELM 7.0View   
3EIF2S2IF2B_HUMANS2----M S GDEMI 55.76%CK2a1-rs HPRD:04882(in vitro)  ViewAnalyzing
4EIF2S2IF2B_HUMANS2----M S GDEMI 55.76%CK2a1 HPRD:04882(in vitro)  ViewAnalyzing
5EIF2S2IF2B_HUMANS13FDPTM S KKKKK 43.75% HPRD:04882(in vitro)View   
6EIF2S2IF2B_HUMANS67RKKDA S DDLDD 41.62% Swiss-Prot 55.0 (Similarity)View   
7EIF2S2IF2B_HUMANS67RKKDA S DDLDD 41.62%CK2a1-rs HPRD:04882(in vitro)  ViewAnalyzing
8EIF2S2IF2B_HUMANS67RKKDA S DDLDD 41.62%CK2a1 HPRD:04882(in vitro)  ViewAnalyzing
9EIF2S2IF2B_HUMANS218GTKKT S FVNFT 35.76% HPRD:04882(in vitro)View