Regulatory Network in Protein Phosphorylation
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Substrate: EIF4EBP1

Description: Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1)(eIF4E-binding protein 1) (Phosphorylated heat- and acid-stableprotein regulated by insulin 1) (PHAS-I).

Ensembl ID: ENSG00000187840

UniprotKB/SwissProt: 4EBP1_HUMAN (Q13541)

Function: Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
PDB:1WKW
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of EIF4EBP1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1EIF4EBP14EBP1_HUMANS8GGSSC S QTPSR 38.75%ATM Phospho.ELM 7.0  ViewAnalyzing
2EIF4EBP14EBP1_HUMANT36PGDYS T TPGGT 30.68%MSK1 HPRD:03746(in vitro)  ViewAnalyzing
3EIF4EBP14EBP1_HUMANT37GDYST T PGGTL 17.62%AKT1 HPRD:03746(in vitro)  ViewAnalyzing
4EIF4EBP14EBP1_HUMANT37GDYST T PGGTL 17.62%FRAP(mTOR) Phospho.ELM 7.0 ViewAnalyzing
5EIF4EBP14EBP1_HUMANT37GDYST T PGGTL 17.62%Erk2 HPRD:03746(in vitro;in vivo)  ViewAnalyzing
6EIF4EBP14EBP1_HUMANT37GDYST T PGGTL 17.62%FRAP HPRD:03746(in vitro;in vivo)  ViewAnalyzing
7EIF4EBP14EBP1_HUMANT37GDYST T PGGTL 17.62%p38a HPRD:03746(in vitro;in vivo)  ViewAnalyzing
8EIF4EBP14EBP1_HUMANT45GTLFS T TPGGT 29.67%MSK1 HPRD:03746(in vitro)  ViewAnalyzing
9EIF4EBP14EBP1_HUMANT46TLFST T PGGTR 20.81%p38a HPRD:03746(in vitro;in vivo)  ViewAnalyzing
10EIF4EBP14EBP1_HUMANT46TLFST T PGGTR 20.81% Swiss-Prot 55.0 View   
11EIF4EBP14EBP1_HUMANT46TLFST T PGGTR 20.81%Erk2 HPRD:03746(in vitro;in vivo)  ViewAnalyzing
12EIF4EBP14EBP1_HUMANT46TLFST T PGGTR 20.81%AKT1 HPRD:03746(in vitro)  ViewAnalyzing
13EIF4EBP14EBP1_HUMANT46TLFST T PGGTR 20.81%FRAP(mTOR) Phospho.ELM 7.0 ViewAnalyzing
14EIF4EBP14EBP1_HUMANT46TLFST T PGGTR 20.81%FRAP HPRD:03746(in vitro;in vivo)  ViewAnalyzing
15EIF4EBP14EBP1_HUMANS65MECRN S PVTKT 11.03%AKT1 HPRD:03746(in vitro)  ViewAnalyzing
16EIF4EBP14EBP1_HUMANS65MECRN S PVTKT 11.03%FRAP(mTOR) Phospho.ELM 7.0 ViewAnalyzing
17EIF4EBP14EBP1_HUMANS65MECRN S PVTKT 11.03%Erk2 HPRD:03746(in vitro;in vivo)  ViewAnalyzing
18EIF4EBP14EBP1_HUMANS65MECRN S PVTKT 11.03%p38a HPRD:03746(in vitro;in vivo)  ViewAnalyzing
19EIF4EBP14EBP1_HUMANS65MECRN S PVTKT 11.03%MSK1 HPRD:03746(in vitro)  ViewAnalyzing
20EIF4EBP14EBP1_HUMANS65MECRN S PVTKT 11.03%Erk1(MAPK3) Swiss-Prot 55.0  ViewAnalyzing
21EIF4EBP14EBP1_HUMANS65MECRN S PVTKT 11.03%Erk2(MAPK1) Swiss-Prot 55.0  ViewAnalyzing
22EIF4EBP14EBP1_HUMANS65MECRN S PVTKT 11.03%FRAP HPRD:03746(in vitro;in vivo)  ViewAnalyzing
23EIF4EBP14EBP1_HUMANT68RNSPV T KTPPR 32.36% Swiss-Prot 55.0 View   
24EIF4EBP14EBP1_HUMANT70SPVTK T PPRDL 29.20%Erk2 HPRD:03746(in vitro;in vivo)  ViewAnalyzing
25EIF4EBP14EBP1_HUMANT70SPVTK T PPRDL 29.20%FRAP HPRD:03746(in vitro;in vivo)  ViewAnalyzing
26EIF4EBP14EBP1_HUMANT70SPVTK T PPRDL 29.20%FRAP(mTOR) Phospho.ELM 7.0 ViewAnalyzing
27EIF4EBP14EBP1_HUMANT70SPVTK T PPRDL 29.20% Swiss-Prot 55.0 View   
28EIF4EBP14EBP1_HUMANS83IPGVT S PSSDE 22.00%FRAP(mTOR) Phospho.ELM 7.0 ViewAnalyzing
29EIF4EBP14EBP1_HUMANS83IPGVT S PSSDE 22.00%FRAP HPRD:03746(in vitro;in vivo)  ViewAnalyzing
30EIF4EBP14EBP1_HUMANS83IPGVT S PSSDE 22.00%Erk2 HPRD:03746(in vitro;in vivo)  ViewAnalyzing
31EIF4EBP14EBP1_HUMANS94PPMEA S QSHLR 20.93% Swiss-Prot 55.0 View   
32EIF4EBP14EBP1_HUMANS101SHLRN S PEDKR 24.19% Swiss-Prot 55.0 View   
33EIF4EBP14EBP1_HUMANS101SHLRN S PEDKR 24.19% HPRD:03746(in vivo)View   
34EIF4EBP14EBP1_HUMANS101SHLRN S PEDKR 24.19%FRAP(mTOR) Phospho.ELM 7.0 ViewAnalyzing
35EIF4EBP14EBP1_HUMANS112AGGEE S QFEMD 35.55%CK2a1-rs HPRD:03746(in vitro;in vivo)  ViewAnalyzing
36EIF4EBP14EBP1_HUMANS112AGGEE S QFEMD 35.55%CK2a1 HPRD:03746(in vitro;in vivo)  ViewAnalyzing
37EIF4EBP14EBP1_HUMANS112AGGEE S QFEMD 35.55%CK2a2 HPRD:03746(in vitro;in vivo)  ViewAnalyzing
38EIF4EBP14EBP1_HUMANS112AGGEE S QFEMD 35.55%ATM Phospho.ELM 7.0  ViewAnalyzing
39EIF4EBP14EBP1_HUMANS112AGGEE S QFEMD 35.55% Swiss-Prot 55.0 View   
40EIF4EBP14EBP1_HUMANS112AGGEE S QFEMD 35.55%ATM HPRD:03746(in vitro;in vivo)  ViewAnalyzing